SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989137715> ?p ?o ?g. }

Showing items 1 to 100 of ±106 with 100 items per page.

W1989137715 endingPage "286" @default.
W1989137715 startingPage "281" @default.
W1989137715 abstract "Matrin 3 is a nuclear matrix protein that has been implicated in interacting with other nuclear proteins to anchor hyperedited RNAs to the nuclear matrix, in modulating the activity of proximal promoters, and as the main PKA substrate following NMDA receptor activation. In our proteome-wide selections for calmodulin (CaM) binding proteins and for caspase substrates using mRNA-displayed human proteome libraries, matrin 3 was identified as both a Ca2+-dependent CaM-binding protein and a downstream substrate of caspases. We report here, the in vitro characterization of the CaM-binding motif and the caspase cleavage site on matrin 3. Significantly, the Ca2+/CaM-binding motif is partially overlapped by the RRM of matrin 3 and is also very close to the bipartite NLS that is essential for its nuclear localization. The caspase cleavage site is downstream of the NLS but upstream of the second U1-like zinc finger. Our results suggest that the functions of matrin 3 could be regulated by both Ca2+-dependent interaction with CaM and caspase-mediated cleavage." @default.
W1989137715 created "2016-06-24" @default.
W1989137715 creator A5016019197 @default.
W1989137715 creator A5053322097 @default.
W1989137715 creator A5068494127 @default.
W1989137715 date "2007-09-01" @default.
W1989137715 modified "2023-10-17" @default.
W1989137715 title "Matrin 3 is a Ca2+/calmodulin-binding protein cleaved by caspases" @default.
W1989137715 cites W1485297825 @default.
W1989137715 cites W1504251053 @default.
W1989137715 cites W1544820414 @default.
W1989137715 cites W1607531254 @default.
W1989137715 cites W1767701883 @default.
W1989137715 cites W1965608446 @default.
W1989137715 cites W1974764190 @default.
W1989137715 cites W1978382819 @default.
W1989137715 cites W1983476428 @default.
W1989137715 cites W1994110496 @default.
W1989137715 cites W1994803330 @default.
W1989137715 cites W2041676007 @default.
W1989137715 cites W2069590842 @default.
W1989137715 cites W2073401178 @default.
W1989137715 cites W2074982435 @default.
W1989137715 cites W2080108863 @default.
W1989137715 cites W2104211616 @default.
W1989137715 cites W2129777487 @default.
W1989137715 cites W2172712627 @default.
W1989137715 doi "https://doi.org/10.1016/j.bbrc.2007.06.156" @default.
W1989137715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17658460" @default.
W1989137715 hasPublicationYear "2007" @default.
W1989137715 type Work @default.
W1989137715 sameAs 1989137715 @default.
W1989137715 citedByCount "33" @default.
W1989137715 countsByYear W19891377152012 @default.
W1989137715 countsByYear W19891377152013 @default.
W1989137715 countsByYear W19891377152014 @default.
W1989137715 countsByYear W19891377152015 @default.
W1989137715 countsByYear W19891377152016 @default.
W1989137715 countsByYear W19891377152017 @default.
W1989137715 countsByYear W19891377152018 @default.
W1989137715 countsByYear W19891377152020 @default.
W1989137715 countsByYear W19891377152021 @default.
W1989137715 countsByYear W19891377152022 @default.
W1989137715 countsByYear W19891377152023 @default.
W1989137715 crossrefType "journal-article" @default.
W1989137715 hasAuthorship W1989137715A5016019197 @default.
W1989137715 hasAuthorship W1989137715A5053322097 @default.
W1989137715 hasAuthorship W1989137715A5068494127 @default.
W1989137715 hasConcept C104317684 @default.
W1989137715 hasConcept C104397665 @default.
W1989137715 hasConcept C107824862 @default.
W1989137715 hasConcept C151730666 @default.
W1989137715 hasConcept C175156509 @default.
W1989137715 hasConcept C181199279 @default.
W1989137715 hasConcept C185592680 @default.
W1989137715 hasConcept C190283241 @default.
W1989137715 hasConcept C24284526 @default.
W1989137715 hasConcept C29512474 @default.
W1989137715 hasConcept C29688787 @default.
W1989137715 hasConcept C31573885 @default.
W1989137715 hasConcept C43369102 @default.
W1989137715 hasConcept C55493867 @default.
W1989137715 hasConcept C86339819 @default.
W1989137715 hasConcept C86803240 @default.
W1989137715 hasConcept C95444343 @default.
W1989137715 hasConcept C98424977 @default.
W1989137715 hasConceptScore W1989137715C104317684 @default.
W1989137715 hasConceptScore W1989137715C104397665 @default.
W1989137715 hasConceptScore W1989137715C107824862 @default.
W1989137715 hasConceptScore W1989137715C151730666 @default.
W1989137715 hasConceptScore W1989137715C175156509 @default.
W1989137715 hasConceptScore W1989137715C181199279 @default.
W1989137715 hasConceptScore W1989137715C185592680 @default.
W1989137715 hasConceptScore W1989137715C190283241 @default.
W1989137715 hasConceptScore W1989137715C24284526 @default.
W1989137715 hasConceptScore W1989137715C29512474 @default.
W1989137715 hasConceptScore W1989137715C29688787 @default.
W1989137715 hasConceptScore W1989137715C31573885 @default.
W1989137715 hasConceptScore W1989137715C43369102 @default.
W1989137715 hasConceptScore W1989137715C55493867 @default.
W1989137715 hasConceptScore W1989137715C86339819 @default.
W1989137715 hasConceptScore W1989137715C86803240 @default.
W1989137715 hasConceptScore W1989137715C95444343 @default.
W1989137715 hasConceptScore W1989137715C98424977 @default.
W1989137715 hasIssue "2" @default.
W1989137715 hasLocation W19891377151 @default.
W1989137715 hasLocation W19891377152 @default.
W1989137715 hasOpenAccess W1989137715 @default.
W1989137715 hasPrimaryLocation W19891377151 @default.
W1989137715 hasRelatedWork W1583781439 @default.
W1989137715 hasRelatedWork W1976758932 @default.
W1989137715 hasRelatedWork W1993888620 @default.
W1989137715 hasRelatedWork W2037996622 @default.
W1989137715 hasRelatedWork W2088494127 @default.
W1989137715 hasRelatedWork W2404213607 @default.
W1989137715 hasRelatedWork W2949457366 @default.
W1989137715 hasRelatedWork W2949992629 @default.
W1989137715 hasRelatedWork W2949998934 @default.