Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989144464> ?p ?o ?g. }
- W1989144464 endingPage "1270" @default.
- W1989144464 startingPage "1255" @default.
- W1989144464 abstract "The major active product of ghrelin gene is a 28-amino acid peptide acylated at the serine 3 position with an octanoyl group, called simply ghrelin. Ghrelin has a multiplicity of physiological functions, affecting GH release, food intake, energy and glucose homeostasis, gastrointestinal, cardiovascular, pulmonary and immune function, cell proliferation and differentiation and bone physiology. Nevertheless, recent developments have shown that ghrelin gene can generate various bioactive molecules besides ghrelin, mainly des-acyl ghrelin and obestatin, obtained from alternative splicing or from extensive post-translational modification. Although their receptors have not yet been identified, they have already proven to be active, having intriguingly subtle but opposite physiological actions to ghrelin. This suggests the existence of a novel endocrine system with multiple effector elements which not only may have opposite actions but may regulate the action of each other. In this review, we summarize the steps which lead to the production of the different ghrelin gene products and examine the most significant differences between them in terms of structure and actions." @default.
- W1989144464 created "2016-06-24" @default.
- W1989144464 creator A5000574019 @default.
- W1989144464 creator A5007213349 @default.
- W1989144464 date "2008-07-01" @default.
- W1989144464 modified "2023-10-14" @default.
- W1989144464 title "Ghrelin, des-acyl ghrelin and obestatin: Three pieces of the same puzzle" @default.
- W1989144464 cites W1517309712 @default.
- W1989144464 cites W1585363241 @default.
- W1989144464 cites W1596010380 @default.
- W1989144464 cites W1901716085 @default.
- W1989144464 cites W1963930004 @default.
- W1989144464 cites W1964484977 @default.
- W1989144464 cites W1965984308 @default.
- W1989144464 cites W1968743784 @default.
- W1989144464 cites W1971922621 @default.
- W1989144464 cites W1973600888 @default.
- W1989144464 cites W1973894166 @default.
- W1989144464 cites W1974118452 @default.
- W1989144464 cites W1981016212 @default.
- W1989144464 cites W1983928000 @default.
- W1989144464 cites W1986700733 @default.
- W1989144464 cites W1986768602 @default.
- W1989144464 cites W1988022480 @default.
- W1989144464 cites W1988588946 @default.
- W1989144464 cites W1990070983 @default.
- W1989144464 cites W1991153536 @default.
- W1989144464 cites W1993103866 @default.
- W1989144464 cites W1994074305 @default.
- W1989144464 cites W1994176470 @default.
- W1989144464 cites W1995734405 @default.
- W1989144464 cites W1996284417 @default.
- W1989144464 cites W1998289958 @default.
- W1989144464 cites W1998991189 @default.
- W1989144464 cites W1999244000 @default.
- W1989144464 cites W2001161494 @default.
- W1989144464 cites W2004381364 @default.
- W1989144464 cites W2004538736 @default.
- W1989144464 cites W2005168887 @default.
- W1989144464 cites W2005380415 @default.
- W1989144464 cites W2006920408 @default.
- W1989144464 cites W2007246387 @default.
- W1989144464 cites W2007982074 @default.
- W1989144464 cites W2008646871 @default.
- W1989144464 cites W2014155696 @default.
- W1989144464 cites W2014213263 @default.
- W1989144464 cites W2014919357 @default.
- W1989144464 cites W2017392274 @default.
- W1989144464 cites W2018492121 @default.
- W1989144464 cites W2019112734 @default.
- W1989144464 cites W2019190598 @default.
- W1989144464 cites W2022826560 @default.
- W1989144464 cites W2024100561 @default.
- W1989144464 cites W2027108665 @default.
- W1989144464 cites W2027963861 @default.
- W1989144464 cites W2031585557 @default.
- W1989144464 cites W2032088715 @default.
- W1989144464 cites W2032659853 @default.
- W1989144464 cites W2035887328 @default.
- W1989144464 cites W2037328290 @default.
- W1989144464 cites W2037693366 @default.
- W1989144464 cites W2039814536 @default.
- W1989144464 cites W2040478405 @default.
- W1989144464 cites W2040509326 @default.
- W1989144464 cites W2041107250 @default.
- W1989144464 cites W2046402357 @default.
- W1989144464 cites W2049261124 @default.
- W1989144464 cites W2049506165 @default.
- W1989144464 cites W2051592195 @default.
- W1989144464 cites W2052692391 @default.
- W1989144464 cites W2052970910 @default.
- W1989144464 cites W2053680491 @default.
- W1989144464 cites W2053869270 @default.
- W1989144464 cites W2054899525 @default.
- W1989144464 cites W2058063580 @default.
- W1989144464 cites W2061776382 @default.
- W1989144464 cites W2062048887 @default.
- W1989144464 cites W2063816197 @default.
- W1989144464 cites W2065136507 @default.
- W1989144464 cites W2069231788 @default.
- W1989144464 cites W2069552504 @default.
- W1989144464 cites W2069661801 @default.
- W1989144464 cites W2070849419 @default.
- W1989144464 cites W2071668556 @default.
- W1989144464 cites W2071952874 @default.
- W1989144464 cites W2072911841 @default.
- W1989144464 cites W2074134450 @default.
- W1989144464 cites W2075169756 @default.
- W1989144464 cites W2077356451 @default.
- W1989144464 cites W2077982572 @default.
- W1989144464 cites W2079081072 @default.
- W1989144464 cites W2080402651 @default.
- W1989144464 cites W2082296856 @default.
- W1989144464 cites W2083560906 @default.
- W1989144464 cites W2085536990 @default.
- W1989144464 cites W2085807747 @default.
- W1989144464 cites W2086977100 @default.
- W1989144464 cites W2089517606 @default.