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- W1989156724 abstract "Adenosine 5′-hexadecylphosphate (AMPC16) is a mimic of palmitoyl-AMP, a transient intermediate of the acyl-CoA synthetic reaction, and thus could effectively inhibit the activity of palmitoyl-CoA synthetase of Saccharomyces cerevisiae. AMPC16 inhibited the cellular incorporation of [3H]palmitic acid into phospholipids, in which such an inhibition was most significantly detected in the fraction containing both phosphatidylinositol (PI) and phosphatidylserine (PS). A pulse-chase experiment revealed the loss of PI and PS accompanied with accumulation of free fatty acids in AMPC16-treated cells. AMPC16-induced events suggested that Faa1p, the major acyl-CoA synthetase isozyme, is functional for phospholipid reconstitution in the exponential growth phase." @default.
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- W1989156724 date "2001-01-01" @default.
- W1989156724 modified "2023-09-24" @default.
- W1989156724 title "Evaluation of Adenosine 5'-Hexadecylphosphate as an Inhibitor of Acyl-CoA Synthetase Isozyme Functional for Phospholipid Reconstitution in the Yeast Saccharomyces cerevisiae." @default.
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- W1989156724 doi "https://doi.org/10.1263/jbb.92.475" @default.
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