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• W1989163181 abstract "The hippocampus has been implicated in aspects of spatial memory. Its ability to generate new neurons has been suggested to play a role in memory formation. Hippocampal serotonin (5-HT) neurotransmission has also been proposed as a contributor to memory processing. Studies have shown that the 5-HT7 receptor is present in the hippocampus in relatively high abundance. Thus the aim of the present study was to investigate the possible role of the 5-HT7 receptor in spatial memory using 5-HT7 receptor-deficient mice (5-HT7−/−). A hippocampus-associated spatial memory deficit in 5-HT7−/− mice was demonstrated using a novel location/novel object test. A similar reduction in novel location exploration was observed in C57BL/6J mice treated with the selective 5-HT7 receptor antagonist SB-269970. These findings prompted an extended analysis using the Barnes maze demonstrating that 5-HT7−/− mice were less efficient in accommodating to changes in spatial arrangement than 5-HT7+/+ mice. 5-HT7−/− mice had specific impairments in memory compilation required for resolving spatial tasks, which resulted in impaired allocentric spatial memory whereas egocentric spatial memory remained intact after the mice were forced to switch back from striatum-dependent egocentric to hippocampus-dependent allocentric memory. To further investigate the physiological bases underlining these behaviors we compared hippocampal neurogenesis in 5-HT7+/+ and 5-HT7−/− mice employing BrdU immunohistochemistry. The rate of cell proliferation in the dentate gyrus was identical in the two genotypes. From the current data we conclude that the 5-HT7−/− mice performed by remembering a simple sequence of actions that resulted in successfully locating a hidden target in a static environment." @default.
• W1989163181 created "2016-06-24" @default.
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• W1989163181 date "2009-08-24" @default.
• W1989163181 modified "2023-10-18" @default.
• W1989163181 title "The 5-HT7 receptor is involved in allocentric spatial memory information processing" @default.
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• W1989163181 doi "https://doi.org/10.1016/j.bbr.2009.03.011" @default.
• W1989163181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2684518" @default.
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