Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989163969> ?p ?o ?g. }
- W1989163969 endingPage "e1004645" @default.
- W1989163969 startingPage "e1004645" @default.
- W1989163969 abstract "The regulatory logic underlying global transcriptional programs controlling development of visceral organs like the pancreas remains undiscovered. Here, we profiled gene expression in 12 purified populations of fetal and adult pancreatic epithelial cells representing crucial progenitor cell subsets, and their endocrine or exocrine progeny. Using probabilistic models to decode the general programs organizing gene expression, we identified co-expressed gene sets in cell subsets that revealed patterns and processes governing progenitor cell development, lineage specification, and endocrine cell maturation. Purification of Neurog3 mutant cells and module network analysis linked established regulators such as Neurog3 to unrecognized gene targets and roles in pancreas development. Iterative module network analysis nominated and prioritized transcriptional regulators, including diabetes risk genes. Functional validation of a subset of candidate regulators with corresponding mutant mice revealed that the transcription factors Etv1, Prdm16, Runx1t1 and Bcl11a are essential for pancreas development. Our integrated approach provides a unique framework for identifying regulatory genes and functional gene sets underlying pancreas development and associated diseases such as diabetes mellitus." @default.
- W1989163969 created "2016-06-24" @default.
- W1989163969 creator A5005774053 @default.
- W1989163969 creator A5017675008 @default.
- W1989163969 creator A5025918983 @default.
- W1989163969 creator A5039399292 @default.
- W1989163969 creator A5040230088 @default.
- W1989163969 creator A5040945443 @default.
- W1989163969 creator A5045108074 @default.
- W1989163969 creator A5053828984 @default.
- W1989163969 creator A5064892746 @default.
- W1989163969 creator A5070146566 @default.
- W1989163969 creator A5072180343 @default.
- W1989163969 creator A5084049190 @default.
- W1989163969 creator A5089638594 @default.
- W1989163969 creator A5089821227 @default.
- W1989163969 date "2014-10-16" @default.
- W1989163969 modified "2023-10-04" @default.
- W1989163969 title "An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development" @default.
- W1989163969 cites W1524671781 @default.
- W1989163969 cites W1971308324 @default.
- W1989163969 cites W1976209715 @default.
- W1989163969 cites W1979216961 @default.
- W1989163969 cites W1981362835 @default.
- W1989163969 cites W1987101480 @default.
- W1989163969 cites W1990204447 @default.
- W1989163969 cites W1992561101 @default.
- W1989163969 cites W1996549380 @default.
- W1989163969 cites W1998167494 @default.
- W1989163969 cites W1998783289 @default.
- W1989163969 cites W1999202962 @default.
- W1989163969 cites W1999557882 @default.
- W1989163969 cites W2000355031 @default.
- W1989163969 cites W2002005510 @default.
- W1989163969 cites W2003424014 @default.
- W1989163969 cites W2004255821 @default.
- W1989163969 cites W2005688198 @default.
- W1989163969 cites W2012455440 @default.
- W1989163969 cites W2017644488 @default.
- W1989163969 cites W2019670746 @default.
- W1989163969 cites W2019903599 @default.
- W1989163969 cites W2020541351 @default.
- W1989163969 cites W2020947476 @default.
- W1989163969 cites W2022532442 @default.
- W1989163969 cites W2026748222 @default.
- W1989163969 cites W2031878176 @default.
- W1989163969 cites W2031909425 @default.
- W1989163969 cites W2031959007 @default.
- W1989163969 cites W2033380734 @default.
- W1989163969 cites W2041624484 @default.
- W1989163969 cites W2045017910 @default.
- W1989163969 cites W2045646104 @default.
- W1989163969 cites W2047961180 @default.
- W1989163969 cites W2048335012 @default.
- W1989163969 cites W2051278630 @default.
- W1989163969 cites W2052549529 @default.
- W1989163969 cites W2055685165 @default.
- W1989163969 cites W2056203351 @default.
- W1989163969 cites W2064412199 @default.
- W1989163969 cites W2065427389 @default.
- W1989163969 cites W2065459869 @default.
- W1989163969 cites W2075232662 @default.
- W1989163969 cites W2075406901 @default.
- W1989163969 cites W2081152079 @default.
- W1989163969 cites W2082421546 @default.
- W1989163969 cites W2088670929 @default.
- W1989163969 cites W2100350743 @default.
- W1989163969 cites W2102670449 @default.
- W1989163969 cites W2102957529 @default.
- W1989163969 cites W2103391067 @default.
- W1989163969 cites W2104827888 @default.
- W1989163969 cites W2106305501 @default.
- W1989163969 cites W2107386259 @default.
- W1989163969 cites W2107414039 @default.
- W1989163969 cites W2108793401 @default.
- W1989163969 cites W2110509725 @default.
- W1989163969 cites W2110905333 @default.
- W1989163969 cites W2117757143 @default.
- W1989163969 cites W2123802800 @default.
- W1989163969 cites W2126780067 @default.
- W1989163969 cites W2127053639 @default.
- W1989163969 cites W2129092167 @default.
- W1989163969 cites W2130410032 @default.
- W1989163969 cites W2131145532 @default.
- W1989163969 cites W2131934882 @default.
- W1989163969 cites W2137987484 @default.
- W1989163969 cites W2141203840 @default.
- W1989163969 cites W2142382737 @default.
- W1989163969 cites W2142736921 @default.
- W1989163969 cites W2144112229 @default.
- W1989163969 cites W2150892663 @default.
- W1989163969 cites W2152630639 @default.
- W1989163969 cites W2153562609 @default.
- W1989163969 cites W2156314428 @default.
- W1989163969 cites W2158532144 @default.
- W1989163969 cites W2161986541 @default.
- W1989163969 cites W2162995669 @default.
- W1989163969 cites W2163737694 @default.