FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989173885> ?p ?o ?g. }

• W1989173885 endingPage "1696" @default.
• W1989173885 startingPage "1691" @default.
• W1989173885 abstract "Previous experiments have demonstrated that suppression of immune function by either cyclosporin A or by a nucleotide free (NF) diet results in attenuation of morphine withdrawal symptoms in mice suggesting that immune status impacts CNS opioid-related phenomena. The present study elaborates on these initial findings by examining the effects of repletion of the NF diet with nucleotides or their precursors on opiate withdrawal. Female Balb/c mice were divided into six groups: a control group (C) given a standard lab chow diet and five experimental groups each given one of the following diets: a nucleotide free diet (NF); the NF supplemented with 0.25% RNA (NFR 0.25); the NF supplemented with 2.5% RNA (NFR 2.5) the NF supplemented with 0.06% uracil (NFU 0.06); the NF supplemented with 0.6% uracil (NFU 0.6). The mice were made morphine dependent by subcutaneous implantation of morphine pellets. Seventy-two hours after morphine pellet implantation, withdrawal was precipitated with naloxone (2 mg/kg). The mice were then observed and two indicators of withdrawal scored: jumping and diarrhea. The NF, NFR 0.25, NFR 2.5 and NFU 0.06 groups demonstrated significantly attenuation of the withdrawal signs relative to control animals. The NFU 0.6 group, however, had withdrawal scores restored to near control levels for both jumping and diarrhea. This suggests that nucleotides, particularly uracil, may play an important role in the immune-to-brain signaling pathway." @default.
• W1989173885 created "2016-06-24" @default.
• W1989173885 creator A5019962786 @default.
• W1989173885 creator A5022687756 @default.
• W1989173885 creator A5022895454 @default.
• W1989173885 creator A5029341031 @default.
• W1989173885 creator A5039325266 @default.
• W1989173885 creator A5053591226 @default.
• W1989173885 creator A5069094963 @default.
• W1989173885 creator A5077978957 @default.
• W1989173885 date "1997-09-01" @default.
• W1989173885 modified "2023-09-25" @default.
• W1989173885 title "Nutritional supplementation of nucleotides restores opioid CNS-mediated phenomena in mice" @default.
• W1989173885 cites W1510301222 @default.
• W1989173885 cites W1571517648 @default.
• W1989173885 cites W1967431072 @default.
• W1989173885 cites W1984902110 @default.
• W1989173885 cites W2033759566 @default.
• W1989173885 cites W2038051047 @default.
• W1989173885 cites W2047625098 @default.
• W1989173885 cites W2066999442 @default.
• W1989173885 cites W2089849882 @default.
• W1989173885 cites W2090239250 @default.
• W1989173885 cites W2091949015 @default.
• W1989173885 cites W2092006631 @default.
• W1989173885 cites W2097088407 @default.
• W1989173885 cites W2399045151 @default.
• W1989173885 cites W2415382684 @default.
• W1989173885 doi "https://doi.org/10.1016/s0024-3205(97)00774-1" @default.
• W1989173885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9363984" @default.
• W1989173885 hasPublicationYear "1997" @default.
• W1989173885 type Work @default.
• W1989173885 sameAs 1989173885 @default.
• W1989173885 citedByCount "6" @default.
• W1989173885 countsByYear W19891738852012 @default.
• W1989173885 countsByYear W19891738852014 @default.
• W1989173885 crossrefType "journal-article" @default.
• W1989173885 hasAuthorship W1989173885A5019962786 @default.
• W1989173885 hasAuthorship W1989173885A5022687756 @default.
• W1989173885 hasAuthorship W1989173885A5022895454 @default.
• W1989173885 hasAuthorship W1989173885A5029341031 @default.
• W1989173885 hasAuthorship W1989173885A5039325266 @default.
• W1989173885 hasAuthorship W1989173885A5053591226 @default.
• W1989173885 hasAuthorship W1989173885A5069094963 @default.
• W1989173885 hasAuthorship W1989173885A5077978957 @default.
• W1989173885 hasConcept C104317684 @default.
• W1989173885 hasConcept C126322002 @default.
• W1989173885 hasConcept C134018914 @default.
• W1989173885 hasConcept C170493617 @default.
• W1989173885 hasConcept C185592680 @default.
• W1989173885 hasConcept C203014093 @default.
• W1989173885 hasConcept C2777389121 @default.
• W1989173885 hasConcept C2778750930 @default.
• W1989173885 hasConcept C2779554091 @default.
• W1989173885 hasConcept C2779802037 @default.
• W1989173885 hasConcept C2781063702 @default.
• W1989173885 hasConcept C2781259782 @default.
• W1989173885 hasConcept C512185932 @default.
• W1989173885 hasConcept C552990157 @default.
• W1989173885 hasConcept C55493867 @default.
• W1989173885 hasConcept C67705224 @default.
• W1989173885 hasConcept C71924100 @default.
• W1989173885 hasConcept C86803240 @default.
• W1989173885 hasConcept C8891405 @default.
• W1989173885 hasConceptScore W1989173885C104317684 @default.
• W1989173885 hasConceptScore W1989173885C126322002 @default.
• W1989173885 hasConceptScore W1989173885C134018914 @default.
• W1989173885 hasConceptScore W1989173885C170493617 @default.
• W1989173885 hasConceptScore W1989173885C185592680 @default.
• W1989173885 hasConceptScore W1989173885C203014093 @default.
• W1989173885 hasConceptScore W1989173885C2777389121 @default.
• W1989173885 hasConceptScore W1989173885C2778750930 @default.
• W1989173885 hasConceptScore W1989173885C2779554091 @default.
• W1989173885 hasConceptScore W1989173885C2779802037 @default.
• W1989173885 hasConceptScore W1989173885C2781063702 @default.
• W1989173885 hasConceptScore W1989173885C2781259782 @default.
• W1989173885 hasConceptScore W1989173885C512185932 @default.
• W1989173885 hasConceptScore W1989173885C552990157 @default.
• W1989173885 hasConceptScore W1989173885C55493867 @default.
• W1989173885 hasConceptScore W1989173885C67705224 @default.
• W1989173885 hasConceptScore W1989173885C71924100 @default.
• W1989173885 hasConceptScore W1989173885C86803240 @default.
• W1989173885 hasConceptScore W1989173885C8891405 @default.
• W1989173885 hasIssue "17" @default.
• W1989173885 hasLocation W19891738851 @default.
• W1989173885 hasLocation W19891738852 @default.
• W1989173885 hasOpenAccess W1989173885 @default.
• W1989173885 hasPrimaryLocation W19891738851 @default.
• W1989173885 hasRelatedWork W1971852532 @default.
• W1989173885 hasRelatedWork W1973483386 @default.
• W1989173885 hasRelatedWork W2008906080 @default.
• W1989173885 hasRelatedWork W2057691129 @default.
• W1989173885 hasRelatedWork W2087338101 @default.
• W1989173885 hasRelatedWork W2088121632 @default.
• W1989173885 hasRelatedWork W2089059201 @default.
• W1989173885 hasRelatedWork W2162607362 @default.
• W1989173885 hasRelatedWork W2399840801 @default.
• W1989173885 hasRelatedWork W2748952813 @default.

• next