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- W1989183743 abstract "The replication of circular DNA faces topological obstacles that need to be overcome to allow the complete duplication and separation of newly replicated molecules. Small bacterial plasmids provide a perfect model system to study the interplay between DNA helicases, polymerases, topoisomerases and the overall architecture of partially replicated molecules. Recent studies have shown that partially replicated circular molecules have an amazing ability to form various types of structures (supercoils, precatenanes, knots and catenanes) that help to accommodate the dynamic interplay between duplex unwinding at the replication fork and DNA unlinking by topoisomerases." @default.
- W1989183743 created "2016-06-24" @default.
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- W1989183743 date "2004-03-01" @default.
- W1989183743 modified "2023-10-08" @default.
- W1989183743 title "A topological view of the replicon" @default.
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- W1989183743 doi "https://doi.org/10.1038/sj.embor.7400101" @default.
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