Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989201738> ?p ?o ?g. }
- W1989201738 endingPage "4408" @default.
- W1989201738 startingPage "4402" @default.
- W1989201738 abstract "Several studies indicate that spindle microtubules determine the position of the cleavage plane at the end of cell division, but their exact role in triggering the formation and ingression of the cleavage furrow is still unclear. Here we show that in Drosophila depletion of either the GAP (GTPase-activating protein) or the kinesin-like subunit of the evolutionary conserved centralspindlin complex prevents furrowing without affecting the association of astral microtubules with the cell cortex. Moreover, time-lapse imaging indicates that astral microtubules serve to deliver the centralspindlin complex to the equatorial cortex just before furrow formation. However, when the GAP-signaling component was mislocalized around the entire cortex using a membrane-tethering motif, this caused ectopic furrowing even in the absence of its motor partner. Thus, the GAP component of centralspindlin is both necessary and sufficient for furrow formation and ingression and astral microtubules provide a route for its delivery to the cleavage site." @default.
- W1989201738 created "2016-06-24" @default.
- W1989201738 creator A5012637821 @default.
- W1989201738 creator A5036712725 @default.
- W1989201738 creator A5074360175 @default.
- W1989201738 creator A5088936355 @default.
- W1989201738 date "2006-11-01" @default.
- W1989201738 modified "2023-09-23" @default.
- W1989201738 title "RacGAP50C is sufficient to signal cleavage furrow formation during cytokinesis" @default.
- W1989201738 cites W1966855723 @default.
- W1989201738 cites W1995136282 @default.
- W1989201738 cites W1999077006 @default.
- W1989201738 cites W2002367145 @default.
- W1989201738 cites W2002964349 @default.
- W1989201738 cites W2006229889 @default.
- W1989201738 cites W2011833766 @default.
- W1989201738 cites W2012212144 @default.
- W1989201738 cites W2019808498 @default.
- W1989201738 cites W2030926402 @default.
- W1989201738 cites W2045644511 @default.
- W1989201738 cites W2050892933 @default.
- W1989201738 cites W2060046714 @default.
- W1989201738 cites W2062452071 @default.
- W1989201738 cites W2063767869 @default.
- W1989201738 cites W2067666713 @default.
- W1989201738 cites W2079168517 @default.
- W1989201738 cites W2084912243 @default.
- W1989201738 cites W2089509895 @default.
- W1989201738 cites W2089876987 @default.
- W1989201738 cites W2094290169 @default.
- W1989201738 cites W2100889269 @default.
- W1989201738 cites W2103206182 @default.
- W1989201738 cites W2107758511 @default.
- W1989201738 cites W2116463110 @default.
- W1989201738 cites W2119686201 @default.
- W1989201738 cites W2120383922 @default.
- W1989201738 cites W2123924160 @default.
- W1989201738 cites W2134666283 @default.
- W1989201738 cites W2140858258 @default.
- W1989201738 cites W2143596074 @default.
- W1989201738 cites W2151068428 @default.
- W1989201738 cites W2154258409 @default.
- W1989201738 cites W2155733462 @default.
- W1989201738 cites W2161614836 @default.
- W1989201738 cites W2167324829 @default.
- W1989201738 cites W2170533230 @default.
- W1989201738 cites W2171942339 @default.
- W1989201738 doi "https://doi.org/10.1242/jcs.03210" @default.
- W1989201738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17032738" @default.
- W1989201738 hasPublicationYear "2006" @default.
- W1989201738 type Work @default.
- W1989201738 sameAs 1989201738 @default.
- W1989201738 citedByCount "71" @default.
- W1989201738 countsByYear W19892017382012 @default.
- W1989201738 countsByYear W19892017382013 @default.
- W1989201738 countsByYear W19892017382014 @default.
- W1989201738 countsByYear W19892017382015 @default.
- W1989201738 countsByYear W19892017382016 @default.
- W1989201738 countsByYear W19892017382017 @default.
- W1989201738 countsByYear W19892017382018 @default.
- W1989201738 countsByYear W19892017382019 @default.
- W1989201738 countsByYear W19892017382020 @default.
- W1989201738 countsByYear W19892017382021 @default.
- W1989201738 countsByYear W19892017382022 @default.
- W1989201738 countsByYear W19892017382023 @default.
- W1989201738 crossrefType "journal-article" @default.
- W1989201738 hasAuthorship W1989201738A5012637821 @default.
- W1989201738 hasAuthorship W1989201738A5036712725 @default.
- W1989201738 hasAuthorship W1989201738A5074360175 @default.
- W1989201738 hasAuthorship W1989201738A5088936355 @default.
- W1989201738 hasBestOaLocation W19892017382 @default.
- W1989201738 hasConcept C134867827 @default.
- W1989201738 hasConcept C142669718 @default.
- W1989201738 hasConcept C1491633281 @default.
- W1989201738 hasConcept C151730666 @default.
- W1989201738 hasConcept C175156509 @default.
- W1989201738 hasConcept C20418707 @default.
- W1989201738 hasConcept C204462481 @default.
- W1989201738 hasConcept C43369102 @default.
- W1989201738 hasConcept C45472230 @default.
- W1989201738 hasConcept C47432576 @default.
- W1989201738 hasConcept C54355233 @default.
- W1989201738 hasConcept C85813293 @default.
- W1989201738 hasConcept C86803240 @default.
- W1989201738 hasConcept C95444343 @default.
- W1989201738 hasConcept C9565192 @default.
- W1989201738 hasConceptScore W1989201738C134867827 @default.
- W1989201738 hasConceptScore W1989201738C142669718 @default.
- W1989201738 hasConceptScore W1989201738C1491633281 @default.
- W1989201738 hasConceptScore W1989201738C151730666 @default.
- W1989201738 hasConceptScore W1989201738C175156509 @default.
- W1989201738 hasConceptScore W1989201738C20418707 @default.
- W1989201738 hasConceptScore W1989201738C204462481 @default.
- W1989201738 hasConceptScore W1989201738C43369102 @default.
- W1989201738 hasConceptScore W1989201738C45472230 @default.
- W1989201738 hasConceptScore W1989201738C47432576 @default.
- W1989201738 hasConceptScore W1989201738C54355233 @default.
- W1989201738 hasConceptScore W1989201738C85813293 @default.