FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989226644> ?p ?o ?g. }

• W1989226644 endingPage "14175" @default.
• W1989226644 startingPage "14169" @default.
• W1989226644 abstract "In cultured rat vascular smooth muscle cells, angiotensin II (Ang II) induced a rapid increase in mitogen-activated protein kinase (MAPK) activity through the Ang II type 1 receptor, which was insensitive to pertussis toxin but was abolished by the phospholipase C inhibitor, U73122. The Ang II-induced MAPK activation was not affected by the protein kinase C inhibitor, GF109203X, and was only partially impaired by pretreatment with a phorbol ester, whereas both treatments completely prevented MAPK activation by the phorbol ester. Intracellular Ca²⁺ chelation by TMB-8, but not extracellular Ca²⁺ chelation or inhibition of Ca²⁺ influx, abolished Ang II-induced MAPK activation. The calmodulin inhibitor, calmidazolium, and the tyrosine kinase inhibitor, genistein, completely blocked MAPK activation by Ang II as well as by the Ca²⁺ ionophore A23187. Ang II caused a rapid increase in the binding of GTP to p21^ras, and this was inhibited by genistein, TMB-8, and calmidazolium but not by pertussis toxin or GF109203X. These data suggest that Ang II-induced MAPK activation through the Ang II type 1 receptor could be mediated by p21^ras activation through a currently unidentified tyrosine kinase that lies downstream of G_q-coupled Ca²⁺/calmodulin signals." @default.
• W1989226644 created "2016-06-24" @default.
• W1989226644 creator A5011779254 @default.
• W1989226644 creator A5041705350 @default.
• W1989226644 creator A5050003828 @default.
• W1989226644 creator A5071830825 @default.
• W1989226644 creator A5088216068 @default.
• W1989226644 date "1996-06-01" @default.
• W1989226644 modified "2023-10-16" @default.
• W1989226644 title "Identification of an Essential Signaling Cascade for Mitogen-activated Protein Kinase Activation by Angiotensin II in Cultured Rat Vascular Smooth Muscle Cells" @default.
• W1989226644 cites W1479814947 @default.
• W1989226644 cites W1519576356 @default.
• W1989226644 cites W1522083389 @default.
• W1989226644 cites W1527240164 @default.
• W1989226644 cites W1528752221 @default.
• W1989226644 cites W1530507460 @default.
• W1989226644 cites W1532123823 @default.
• W1989226644 cites W1542412714 @default.
• W1989226644 cites W1546923686 @default.
• W1989226644 cites W1551079196 @default.
• W1989226644 cites W1565303318 @default.
• W1989226644 cites W1567065545 @default.
• W1989226644 cites W1567867640 @default.
• W1989226644 cites W1571099567 @default.
• W1989226644 cites W1573821584 @default.
• W1989226644 cites W1575840121 @default.
• W1989226644 cites W1576009119 @default.
• W1989226644 cites W1591510379 @default.
• W1989226644 cites W1594412667 @default.
• W1989226644 cites W164957562 @default.
• W1989226644 cites W1679419992 @default.
• W1989226644 cites W1706568612 @default.
• W1989226644 cites W1755902553 @default.
• W1989226644 cites W1829840485 @default.
• W1989226644 cites W1967561584 @default.
• W1989226644 cites W1968874083 @default.
• W1989226644 cites W1969785844 @default.
• W1989226644 cites W1975915718 @default.
• W1989226644 cites W1976052678 @default.
• W1989226644 cites W1976231373 @default.
• W1989226644 cites W1982186905 @default.
• W1989226644 cites W1985873763 @default.
• W1989226644 cites W1989815448 @default.
• W1989226644 cites W1990132316 @default.
• W1989226644 cites W1992494265 @default.
• W1989226644 cites W1992965538 @default.
• W1989226644 cites W1994531989 @default.
• W1989226644 cites W1999788892 @default.
• W1989226644 cites W2002292023 @default.
• W1989226644 cites W2003628336 @default.
• W1989226644 cites W2011653196 @default.
• W1989226644 cites W2014575233 @default.
• W1989226644 cites W2031452885 @default.
• W1989226644 cites W2043623738 @default.
• W1989226644 cites W2049367666 @default.
• W1989226644 cites W2053181724 @default.
• W1989226644 cites W2053286013 @default.
• W1989226644 cites W2057126981 @default.
• W1989226644 cites W2059215487 @default.
• W1989226644 cites W2065927746 @default.
• W1989226644 cites W2066696278 @default.
• W1989226644 cites W2068502127 @default.
• W1989226644 cites W2068936878 @default.
• W1989226644 cites W2069132844 @default.
• W1989226644 cites W2070023258 @default.
• W1989226644 cites W2076679683 @default.
• W1989226644 cites W2080999736 @default.
• W1989226644 cites W2082190322 @default.
• W1989226644 cites W2087375731 @default.
• W1989226644 cites W2088823687 @default.
• W1989226644 cites W2091611649 @default.
• W1989226644 cites W2136189765 @default.
• W1989226644 cites W2142393775 @default.
• W1989226644 cites W2159929332 @default.
• W1989226644 cites W2180781622 @default.
• W1989226644 cites W2186202324 @default.
• W1989226644 cites W2255671787 @default.
• W1989226644 cites W4236401232 @default.
• W1989226644 doi "https://doi.org/10.1074/jbc.271.24.14169" @default.
• W1989226644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8662912" @default.
• W1989226644 hasPublicationYear "1996" @default.
• W1989226644 type Work @default.
• W1989226644 sameAs 1989226644 @default.
• W1989226644 citedByCount "260" @default.
• W1989226644 countsByYear W19892266442012 @default.
• W1989226644 countsByYear W19892266442013 @default.
• W1989226644 countsByYear W19892266442014 @default.
• W1989226644 countsByYear W19892266442015 @default.
• W1989226644 countsByYear W19892266442018 @default.
• W1989226644 countsByYear W19892266442021 @default.
• W1989226644 countsByYear W19892266442023 @default.
• W1989226644 crossrefType "journal-article" @default.
• W1989226644 hasAuthorship W1989226644A5011779254 @default.
• W1989226644 hasAuthorship W1989226644A5041705350 @default.
• W1989226644 hasAuthorship W1989226644A5050003828 @default.
• W1989226644 hasAuthorship W1989226644A5071830825 @default.
• W1989226644 hasAuthorship W1989226644A5088216068 @default.
• W1989226644 hasBestOaLocation W19892266441 @default.

• next