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- W1989229568 abstract "Changes in the production ratio of Aβ42/total might play a role in Alzheimer Disease pathology. However, any physiological mechanism regulating the ratio of Aβ42 production has not been known, so far. Any physiological substances that alter the cleavage precision of presenilin/γ-secretase cleavage were searched. Cell-free γ-secretase assay and purified in vitro γ-secretase assay were performed. The membrane-bound substances from pig brains or cultured cells were fractioned, and supplemented to the assays. We found evidence indicating the existence of physiological substance that dramatically changes the ϵ-cleavage precision, though it was not indispensable for the γ-secretase activity. The factor increases the production ratio of shorter AICDϵ51 (52-99) to longer AICDϵ49 (50-99). Our data suggests that the cleavage precision of γ-secretase could be under physiological regulation in vivo." @default.
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- W1989229568 date "2009-07-01" @default.
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- W1989229568 title "P4-144: Loose membrane-bound endogenous factors might modulates the intramembrane cleavages of βAPP" @default.
- W1989229568 doi "https://doi.org/10.1016/j.jalz.2009.04.812" @default.
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