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• W1989229919 abstract "Inhibition of γ-aminobutyric acid aminotransferase (GABA-AT) could raise the concentration of GABA, an inhibitory neurotransmitter in the human brain, and could have therapeutic applications for a variety of neurological diseases including epilepsy. Four fluorine-containing analogues of GABA with conformations restricted by a cyclohexane ring system were designed and synthesized, but unlike some of their five-membered ring counterparts, minimal inhibition of GABA-AT was observed. It is likely that the rigid chair conformation of these compounds cannot be accommodated well in the enzyme’s active site." @default.
• W1989229919 created "2016-06-24" @default.
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• W1989229919 creator A5078315542 @default.
• W1989229919 date "2006-04-01" @default.
• W1989229919 modified "2023-10-03" @default.
• W1989229919 title "Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase" @default.
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• W1989229919 doi "https://doi.org/10.1016/j.bmc.2005.11.010" @default.
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