FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989247915> ?p ?o ?g. }

• W1989247915 endingPage "308" @default.
• W1989247915 startingPage "299" @default.
• W1989247915 abstract "Citrullination , the conversion of peptidylarginine to peptidylcitrulline is catalyzed by peptidylarginine deiminases (PAD). The expression of PAD isoforms displays great variation among different tissues as demonstrated by PAD mRNA analyses. Here we have analyzed the differential expression of PAD2, PAD4 and PAD6 in mouse tissues at the protein level and by enzymatic activity assays using PAD2 and PAD4 knock-out strains. As expected, no PAD2 expression was detected in the PAD2−/− mice. In contrast, the PAD4 protein was observed in several tissues of the PAD4 knock-out mice, albeit at reduced levels in most tissues, and are therefore referred to as PAD4-low mice. In material from PAD2−/− mice, except for leukocyte lysates, hardly any PAD activity was found and no citrullinated proteins were detected after incubation in the presence of calcium. PAD activity in the PAD4-low mice was similar to that in wild-type mice. In both PAD knock-out strains the expression of PAD6 appeared to be up-regulated in all tissues analyzed, with the exception of spleen and testis. Our data demonstrate that the PAD2 protein is expressed in brain, spinal cord, spleen, skeletal muscle and leukocytes, but not detectably in liver, lung, kidney and testis. PAD4 was detected in each of these tissues, although the expression levels varied. In all tissues where PAD2 was detected, except for blood cells, this PAD isoform appeared to be responsible for virtually all peptidylarginine deiminase activity. ► The PAD2 and PAD4 proteins are differentially expressed in mouse tissues. ► Disruption of the PAD2 gene eliminates PAD activity in many tissues. ► PAD6 protein expression is enhanced in PAD2 knock-out and PAD4-low mice." @default.
• W1989247915 created "2016-06-24" @default.
• W1989247915 creator A5005494840 @default.
• W1989247915 creator A5035348864 @default.
• W1989247915 creator A5053894399 @default.
• W1989247915 creator A5081889079 @default.
• W1989247915 creator A5087041228 @default.
• W1989247915 date "2013-02-01" @default.
• W1989247915 modified "2023-10-06" @default.
• W1989247915 title "Peptidylarginine deiminase expression and activity in PAD2 knock-out and PAD4-low mice" @default.
• W1989247915 cites W1495724207 @default.
• W1989247915 cites W1514133613 @default.
• W1989247915 cites W1562458137 @default.
• W1989247915 cites W1794226295 @default.
• W1989247915 cites W1964310248 @default.
• W1989247915 cites W1965570776 @default.
• W1989247915 cites W1968797334 @default.
• W1989247915 cites W1969515398 @default.
• W1989247915 cites W1974354099 @default.
• W1989247915 cites W1977225908 @default.
• W1989247915 cites W1977877988 @default.
• W1989247915 cites W1980325059 @default.
• W1989247915 cites W1985259859 @default.
• W1989247915 cites W1985596848 @default.
• W1989247915 cites W1987396543 @default.
• W1989247915 cites W1995734706 @default.
• W1989247915 cites W2005699747 @default.
• W1989247915 cites W2006199787 @default.
• W1989247915 cites W2013573826 @default.
• W1989247915 cites W2015297297 @default.
• W1989247915 cites W2020287197 @default.
• W1989247915 cites W2034228147 @default.
• W1989247915 cites W2038970774 @default.
• W1989247915 cites W2048801137 @default.
• W1989247915 cites W2057259507 @default.
• W1989247915 cites W2060275204 @default.
• W1989247915 cites W2065147052 @default.
• W1989247915 cites W2068111179 @default.
• W1989247915 cites W2074253758 @default.
• W1989247915 cites W2081278295 @default.
• W1989247915 cites W2083753771 @default.
• W1989247915 cites W2084234957 @default.
• W1989247915 cites W2086420062 @default.
• W1989247915 cites W2093441490 @default.
• W1989247915 cites W2093483361 @default.
• W1989247915 cites W2102079012 @default.
• W1989247915 cites W2107277218 @default.
• W1989247915 cites W2118217258 @default.
• W1989247915 cites W2135849676 @default.
• W1989247915 cites W2136131602 @default.
• W1989247915 cites W2138526118 @default.
• W1989247915 cites W2151898539 @default.
• W1989247915 cites W2154040419 @default.
• W1989247915 cites W2159254316 @default.
• W1989247915 cites W2168176302 @default.
• W1989247915 cites W2170806891 @default.
• W1989247915 doi "https://doi.org/10.1016/j.biochi.2012.09.029" @default.
• W1989247915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23026755" @default.
• W1989247915 hasPublicationYear "2013" @default.
• W1989247915 type Work @default.
• W1989247915 sameAs 1989247915 @default.
• W1989247915 citedByCount "41" @default.
• W1989247915 countsByYear W19892479152014 @default.
• W1989247915 countsByYear W19892479152015 @default.
• W1989247915 countsByYear W19892479152016 @default.
• W1989247915 countsByYear W19892479152017 @default.
• W1989247915 countsByYear W19892479152018 @default.
• W1989247915 countsByYear W19892479152019 @default.
• W1989247915 countsByYear W19892479152020 @default.
• W1989247915 countsByYear W19892479152021 @default.
• W1989247915 countsByYear W19892479152022 @default.
• W1989247915 countsByYear W19892479152023 @default.
• W1989247915 crossrefType "journal-article" @default.
• W1989247915 hasAuthorship W1989247915A5005494840 @default.
• W1989247915 hasAuthorship W1989247915A5035348864 @default.
• W1989247915 hasAuthorship W1989247915A5053894399 @default.
• W1989247915 hasAuthorship W1989247915A5081889079 @default.
• W1989247915 hasAuthorship W1989247915A5087041228 @default.
• W1989247915 hasConcept C104317684 @default.
• W1989247915 hasConcept C105580179 @default.
• W1989247915 hasConcept C150194340 @default.
• W1989247915 hasConcept C153911025 @default.
• W1989247915 hasConcept C182704531 @default.
• W1989247915 hasConcept C203014093 @default.
• W1989247915 hasConcept C2777468819 @default.
• W1989247915 hasConcept C2779129087 @default.
• W1989247915 hasConcept C2780931953 @default.
• W1989247915 hasConcept C2796436 @default.
• W1989247915 hasConcept C48632299 @default.
• W1989247915 hasConcept C515207424 @default.
• W1989247915 hasConcept C53345823 @default.
• W1989247915 hasConcept C55493867 @default.
• W1989247915 hasConcept C86803240 @default.
• W1989247915 hasConceptScore W1989247915C104317684 @default.
• W1989247915 hasConceptScore W1989247915C105580179 @default.
• W1989247915 hasConceptScore W1989247915C150194340 @default.
• W1989247915 hasConceptScore W1989247915C153911025 @default.
• W1989247915 hasConceptScore W1989247915C182704531 @default.

• next