FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989261293> ?p ?o ?g. }

• W1989261293 endingPage "870" @default.
• W1989261293 startingPage "862" @default.
• W1989261293 abstract "One of the hallmarks in rheumatoid arthritis (RA) is the intense activation of the monocyte-macrophage system. In the present investigation, the modulation of blood monocyte activation was studied with regard to the secretion of cytokines and inflammatory mediators, and to the expression of cytokine receptors. Patients with severe active RA underwent repeated leukapheresis procedures that removed all circulating monocytes. Highly enriched monocyte preparations from the first and third leukapheresis were studied. There were striking differences between the two monocyte populations. Cells obtained from the first leukapheresis constitutively released large amounts of prostaglandin E2 (PGE2), neopterin, interleukin 1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha). In particular, IL-1 beta and neopterin production were further enhanced by stimulation with either interferon-gamma (IFN-gamma) or TNF-alpha without a synergistic effect. In contrast, cells derived from the third leukapheresis procedure showed a close to normal activation status with only low levels of cytokine and mediator production as well as a reduced response to cytokine stimulation. The number of the receptors for IFN-gamma and TNF-alpha was not changed between first and third leukapheresis. However, TNF-binding capacity was only detectable upon acid treatment of freshly isolated monocytes. A further upregulation was noted upon 24 h in vitro culture, suggesting occupation of membrane receptors and receptor down-regulation by endogenously produced TNF-alpha. Northern blot analysis of cytokine gene expression was in good correlation with the amount of mediators determined on the protein level. These data indicate that cells of the monocyte-macrophage system are already highly activated in the peripheral blood in RA patients with active disease. These cells can be efficiently removed by repeated leukapheresis and are replenished by monocytes that have, with respect to cytokine and mediator production, a considerably lower activation status." @default.
• W1989261293 created "2016-06-24" @default.
• W1989261293 creator A5019904842 @default.
• W1989261293 creator A5035903343 @default.
• W1989261293 creator A5062296202 @default.
• W1989261293 creator A5062769134 @default.
• W1989261293 creator A5066746944 @default.
• W1989261293 creator A5086002702 @default.
• W1989261293 date "1993-03-01" @default.
• W1989261293 modified "2023-09-23" @default.
• W1989261293 title "Modulation of monocyte activation in patients with rheumatoid arthritis by leukapheresis therapy." @default.
• W1989261293 cites W1490165777 @default.
• W1989261293 cites W1558221257 @default.
• W1989261293 cites W1582965065 @default.
• W1989261293 cites W1603323164 @default.
• W1989261293 cites W1605473314 @default.
• W1989261293 cites W1625161850 @default.
• W1989261293 cites W175055053 @default.
• W1989261293 cites W1770937742 @default.
• W1989261293 cites W1974885076 @default.
• W1989261293 cites W1979409684 @default.
• W1989261293 cites W1979486202 @default.
• W1989261293 cites W1983582864 @default.
• W1989261293 cites W1986778299 @default.
• W1989261293 cites W1991936450 @default.
• W1989261293 cites W1995948185 @default.
• W1989261293 cites W1996574766 @default.
• W1989261293 cites W2005861330 @default.
• W1989261293 cites W2017720269 @default.
• W1989261293 cites W2018429509 @default.
• W1989261293 cites W2018646337 @default.
• W1989261293 cites W2021746158 @default.
• W1989261293 cites W2025553793 @default.
• W1989261293 cites W2025556833 @default.
• W1989261293 cites W2025853481 @default.
• W1989261293 cites W2028165689 @default.
• W1989261293 cites W2038879439 @default.
• W1989261293 cites W2040817896 @default.
• W1989261293 cites W2044160043 @default.
• W1989261293 cites W2058267243 @default.
• W1989261293 cites W2060333964 @default.
• W1989261293 cites W2070181804 @default.
• W1989261293 cites W2091319309 @default.
• W1989261293 cites W2095657538 @default.
• W1989261293 cites W2098643663 @default.
• W1989261293 cites W2112184650 @default.
• W1989261293 cites W2143522103 @default.
• W1989261293 cites W2152348310 @default.
• W1989261293 cites W2161151160 @default.
• W1989261293 cites W2165233139 @default.
• W1989261293 cites W2406090639 @default.
• W1989261293 cites W2414803612 @default.
• W1989261293 cites W2417613482 @default.
• W1989261293 cites W278241167 @default.
• W1989261293 cites W3176254103 @default.
• W1989261293 doi "https://doi.org/10.1172/jci116307" @default.
• W1989261293 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/288038" @default.
• W1989261293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8450066" @default.
• W1989261293 hasPublicationYear "1993" @default.
• W1989261293 type Work @default.
• W1989261293 sameAs 1989261293 @default.
• W1989261293 citedByCount "78" @default.
• W1989261293 countsByYear W19892612932012 @default.
• W1989261293 countsByYear W19892612932013 @default.
• W1989261293 countsByYear W19892612932015 @default.
• W1989261293 countsByYear W19892612932016 @default.
• W1989261293 countsByYear W19892612932017 @default.
• W1989261293 countsByYear W19892612932018 @default.
• W1989261293 countsByYear W19892612932019 @default.
• W1989261293 countsByYear W19892612932020 @default.
• W1989261293 countsByYear W19892612932021 @default.
• W1989261293 crossrefType "journal-article" @default.
• W1989261293 hasAuthorship W1989261293A5019904842 @default.
• W1989261293 hasAuthorship W1989261293A5035903343 @default.
• W1989261293 hasAuthorship W1989261293A5062296202 @default.
• W1989261293 hasAuthorship W1989261293A5062769134 @default.
• W1989261293 hasAuthorship W1989261293A5066746944 @default.
• W1989261293 hasAuthorship W1989261293A5086002702 @default.
• W1989261293 hasBestOaLocation W19892612931 @default.
• W1989261293 hasConcept C10205521 @default.
• W1989261293 hasConcept C126322002 @default.
• W1989261293 hasConcept C134018914 @default.
• W1989261293 hasConcept C170493617 @default.
• W1989261293 hasConcept C17991360 @default.
• W1989261293 hasConcept C203014093 @default.
• W1989261293 hasConcept C2776603314 @default.
• W1989261293 hasConcept C2777371436 @default.
• W1989261293 hasConcept C2778690821 @default.
• W1989261293 hasConcept C2781184567 @default.
• W1989261293 hasConcept C28328180 @default.
• W1989261293 hasConcept C71924100 @default.
• W1989261293 hasConcept C86803240 @default.
• W1989261293 hasConcept C95444343 @default.
• W1989261293 hasConceptScore W1989261293C10205521 @default.
• W1989261293 hasConceptScore W1989261293C126322002 @default.
• W1989261293 hasConceptScore W1989261293C134018914 @default.
• W1989261293 hasConceptScore W1989261293C170493617 @default.
• W1989261293 hasConceptScore W1989261293C17991360 @default.

• next