FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989261778> ?p ?o ?g. }

• W1989261778 endingPage "169" @default.
• W1989261778 startingPage "165" @default.
• W1989261778 abstract "Quinoline, a hepatocarcinogen, mutates the bacterial tester strains in the presence of the rat liver microsomal enzymes and induces GST-P (placental glutathione S-transferase)-positive foci in a medium-term bioassay system for hepatocarcinogenesis. On the other hand, 3-fluorinated quinoline was neither mutagenic nor carcinogenic in the same assay systems, whereas, 5-fluoroquinoline was mutagenic and carcinogenic. Quinoline was recently demonstrated to be mutagenic in an in vivo mutagenicity assay system using the lacZ-transgenic mouse (MutaMouse). The present study was undertaken to know whether 3-fluoroquinoline would be devoid of in vivo mutagenicity in MutaMouse. Quinoline and 5-fluoroquinoline were also tested in the same system. Mutagenicity was evaluated in the liver, the target organ of quinoline carcinogenesis, and also in the bone marrow and testis. The results strongly indicate that fluorine-substitution at the position-3 of quinoline could be an anti-genotoxic structural modification of quinoline in a wide range of its genotoxic end-points." @default.
• W1989261778 created "2016-06-24" @default.
• W1989261778 creator A5006768230 @default.
• W1989261778 creator A5010967300 @default.
• W1989261778 creator A5046606361 @default.
• W1989261778 creator A5065821856 @default.
• W1989261778 creator A5070698304 @default.
• W1989261778 creator A5071160133 @default.
• W1989261778 date "1998-05-01" @default.
• W1989261778 modified "2023-10-01" @default.
• W1989261778 title "Antimutagenic structural modification of quinoline assessed by an in vivo mutagenesis assay using lacZ-transgenic mice" @default.
• W1989261778 cites W133599854 @default.
• W1989261778 cites W1970468813 @default.
• W1989261778 cites W1973115410 @default.
• W1989261778 cites W1989039762 @default.
• W1989261778 cites W1990869503 @default.
• W1989261778 cites W2011279163 @default.
• W1989261778 cites W2023357879 @default.
• W1989261778 cites W2044575308 @default.
• W1989261778 cites W2048772080 @default.
• W1989261778 cites W2050595882 @default.
• W1989261778 cites W2055553285 @default.
• W1989261778 cites W2079358955 @default.
• W1989261778 cites W2132201218 @default.
• W1989261778 cites W2319347035 @default.
• W1989261778 cites W2319803135 @default.
• W1989261778 cites W2330339879 @default.
• W1989261778 cites W4248208917 @default.
• W1989261778 doi "https://doi.org/10.1016/s1383-5718(98)00029-1" @default.
• W1989261778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9630605" @default.
• W1989261778 hasPublicationYear "1998" @default.
• W1989261778 type Work @default.
• W1989261778 sameAs 1989261778 @default.
• W1989261778 citedByCount "23" @default.
• W1989261778 countsByYear W19892617782012 @default.
• W1989261778 countsByYear W19892617782013 @default.
• W1989261778 countsByYear W19892617782018 @default.
• W1989261778 countsByYear W19892617782020 @default.
• W1989261778 countsByYear W19892617782022 @default.
• W1989261778 crossrefType "journal-article" @default.
• W1989261778 hasAuthorship W1989261778A5006768230 @default.
• W1989261778 hasAuthorship W1989261778A5010967300 @default.
• W1989261778 hasAuthorship W1989261778A5046606361 @default.
• W1989261778 hasAuthorship W1989261778A5065821856 @default.
• W1989261778 hasAuthorship W1989261778A5070698304 @default.
• W1989261778 hasAuthorship W1989261778A5071160133 @default.
• W1989261778 hasConcept C102230213 @default.
• W1989261778 hasConcept C104317684 @default.
• W1989261778 hasConcept C114246631 @default.
• W1989261778 hasConcept C117632636 @default.
• W1989261778 hasConcept C153911025 @default.
• W1989261778 hasConcept C16318435 @default.
• W1989261778 hasConcept C178790620 @default.
• W1989261778 hasConcept C181199279 @default.
• W1989261778 hasConcept C185592680 @default.
• W1989261778 hasConcept C207001950 @default.
• W1989261778 hasConcept C2776309666 @default.
• W1989261778 hasConcept C2776639595 @default.
• W1989261778 hasConcept C2781065037 @default.
• W1989261778 hasConcept C501734568 @default.
• W1989261778 hasConcept C523546767 @default.
• W1989261778 hasConcept C538909803 @default.
• W1989261778 hasConcept C54355233 @default.
• W1989261778 hasConcept C55493867 @default.
• W1989261778 hasConcept C555283112 @default.
• W1989261778 hasConcept C86803240 @default.
• W1989261778 hasConcept C87644729 @default.
• W1989261778 hasConceptScore W1989261778C102230213 @default.
• W1989261778 hasConceptScore W1989261778C104317684 @default.
• W1989261778 hasConceptScore W1989261778C114246631 @default.
• W1989261778 hasConceptScore W1989261778C117632636 @default.
• W1989261778 hasConceptScore W1989261778C153911025 @default.
• W1989261778 hasConceptScore W1989261778C16318435 @default.
• W1989261778 hasConceptScore W1989261778C178790620 @default.
• W1989261778 hasConceptScore W1989261778C181199279 @default.
• W1989261778 hasConceptScore W1989261778C185592680 @default.
• W1989261778 hasConceptScore W1989261778C207001950 @default.
• W1989261778 hasConceptScore W1989261778C2776309666 @default.
• W1989261778 hasConceptScore W1989261778C2776639595 @default.
• W1989261778 hasConceptScore W1989261778C2781065037 @default.
• W1989261778 hasConceptScore W1989261778C501734568 @default.
• W1989261778 hasConceptScore W1989261778C523546767 @default.
• W1989261778 hasConceptScore W1989261778C538909803 @default.
• W1989261778 hasConceptScore W1989261778C54355233 @default.
• W1989261778 hasConceptScore W1989261778C55493867 @default.
• W1989261778 hasConceptScore W1989261778C555283112 @default.
• W1989261778 hasConceptScore W1989261778C86803240 @default.
• W1989261778 hasConceptScore W1989261778C87644729 @default.
• W1989261778 hasIssue "1-3" @default.
• W1989261778 hasLocation W19892617781 @default.
• W1989261778 hasLocation W19892617782 @default.
• W1989261778 hasOpenAccess W1989261778 @default.
• W1989261778 hasPrimaryLocation W19892617781 @default.
• W1989261778 hasRelatedWork W1594770127 @default.
• W1989261778 hasRelatedWork W2002757935 @default.
• W1989261778 hasRelatedWork W2015773382 @default.
• W1989261778 hasRelatedWork W2024756813 @default.
• W1989261778 hasRelatedWork W2064977254 @default.

• next