FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989262521> ?p ?o ?g. }

• W1989262521 endingPage "c283" @default.
• W1989262521 startingPage "c276" @default.
• W1989262521 abstract "<i>Background:</i> Although the mechanism of muscle wasting in end-stage renal disease is not fully understood, there is increasing evidence that acidosis induces muscle protein degradation and could therefore contribute to the loss of muscle protein stores of patients on hemodialysis, a prototypical state of chronic metabolic acidosis (CMA). Because body protein mass is controlled by the balance between synthesis and degradation, protein loss can occur as result of either increased breakdown, impaired synthesis, or both. Correction of acidosis may therefore help to maintain muscle mass and improve the health of patients with CMA. We evaluated whether alkalizing patients on hemodialysis might have a positive effect on protein synthesis and on nutritional parameters. <i>Methods:</i> Eight chronic hemodialysis patients were treated daily with oral sodium bicarbonate (NaHCO₃) supplementation for 10–14 days, yielding a pre-dialytic plasma bicarbonate concentration of 28.6 ±1.6 mmol/l. The fractional synthesis rates (FSR) of muscle protein and albumin were obtained by the L-[²H₅ring]phenylalanine flooding technique. <i>Results:</i> Oral NaHCO₃supplementation induced a significant increase in serum bicarbonate (21.5 ± 3.4 vs. 28.6 ± 1.6 mmol/l; p = 0.018) and blood pH (7.41 vs. 7.46; p = 0.041). The FSR of muscle protein and the FSR of albumin did not change significantly (muscle protein: 2.1 ± 0.2 vs. 2.0 ± 0.5% per day, p = 0.39; albumin: 8.3 ± 2.2 vs. 8.6 ± 2.5% per day, p = 0.31). Plasma concentrations of insulin-like growth factor 1 decreased significantly (33.4 ± 21.3 vs. 25.4 ± 12.3 nmol/l; p = 0.028), whereas thyroid-stimulating hormone, free thyroxin and free triiodothyronine did not change significantly and nutritional parameters showed no improvement. <i>Conclusion:</i> In contrast to other findings, raising the blood pH of dialysis patients was not associated with a positive effect on albumin and muscle protein synthesis, or nutritional and endocrinal parameters." @default.
• W1989262521 created "2016-06-24" @default.
• W1989262521 creator A5003837724 @default.
• W1989262521 creator A5006195679 @default.
• W1989262521 creator A5013913305 @default.
• W1989262521 creator A5022665621 @default.
• W1989262521 creator A5029017035 @default.
• W1989262521 creator A5036559071 @default.
• W1989262521 creator A5036792360 @default.
• W1989262521 creator A5091743543 @default.
• W1989262521 date "2009-06-16" @default.
• W1989262521 modified "2023-09-25" @default.
• W1989262521 title "Does Increasing Blood pH Stimulate Protein Synthesis in Dialysis Patients?" @default.
• W1989262521 cites W154341060 @default.
• W1989262521 cites W1808429138 @default.
• W1989262521 cites W1815740126 @default.
• W1989262521 cites W1841321742 @default.
• W1989262521 cites W1871937327 @default.
• W1989262521 cites W1915463020 @default.
• W1989262521 cites W1931273131 @default.
• W1989262521 cites W1940284292 @default.
• W1989262521 cites W1973445395 @default.
• W1989262521 cites W1979954571 @default.
• W1989262521 cites W1982177153 @default.
• W1989262521 cites W1985211606 @default.
• W1989262521 cites W1994182378 @default.
• W1989262521 cites W2000598582 @default.
• W1989262521 cites W2012225387 @default.
• W1989262521 cites W2017479788 @default.
• W1989262521 cites W2032167410 @default.
• W1989262521 cites W2034302370 @default.
• W1989262521 cites W2037083271 @default.
• W1989262521 cites W2040941129 @default.
• W1989262521 cites W2050197222 @default.
• W1989262521 cites W2062106867 @default.
• W1989262521 cites W2062163699 @default.
• W1989262521 cites W2064023530 @default.
• W1989262521 cites W2066691397 @default.
• W1989262521 cites W2066910356 @default.
• W1989262521 cites W2072287146 @default.
• W1989262521 cites W207408070 @default.
• W1989262521 cites W2078075522 @default.
• W1989262521 cites W2083508036 @default.
• W1989262521 cites W2094089642 @default.
• W1989262521 cites W2106304045 @default.
• W1989262521 cites W2118510223 @default.
• W1989262521 cites W2125397471 @default.
• W1989262521 cites W2134202500 @default.
• W1989262521 cites W2135419782 @default.
• W1989262521 cites W2138740882 @default.
• W1989262521 cites W2142341955 @default.
• W1989262521 cites W2153705946 @default.
• W1989262521 cites W2156672258 @default.
• W1989262521 cites W2162657507 @default.
• W1989262521 cites W2165630567 @default.
• W1989262521 cites W2169615514 @default.
• W1989262521 cites W2175727897 @default.
• W1989262521 cites W2274824642 @default.
• W1989262521 cites W2341277428 @default.
• W1989262521 cites W2405029461 @default.
• W1989262521 cites W2413210027 @default.
• W1989262521 cites W2414738104 @default.
• W1989262521 cites W2434772191 @default.
• W1989262521 cites W41005115 @default.
• W1989262521 cites W5909904 @default.
• W1989262521 cites W2521739899 @default.
• W1989262521 doi "https://doi.org/10.1159/000224795" @default.
• W1989262521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19546588" @default.
• W1989262521 hasPublicationYear "2009" @default.
• W1989262521 type Work @default.
• W1989262521 sameAs 1989262521 @default.
• W1989262521 citedByCount "5" @default.
• W1989262521 countsByYear W19892625212012 @default.
• W1989262521 countsByYear W19892625212016 @default.
• W1989262521 countsByYear W19892625212017 @default.
• W1989262521 countsByYear W19892625212022 @default.
• W1989262521 crossrefType "journal-article" @default.
• W1989262521 hasAuthorship W1989262521A5003837724 @default.
• W1989262521 hasAuthorship W1989262521A5006195679 @default.
• W1989262521 hasAuthorship W1989262521A5013913305 @default.
• W1989262521 hasAuthorship W1989262521A5022665621 @default.
• W1989262521 hasAuthorship W1989262521A5029017035 @default.
• W1989262521 hasAuthorship W1989262521A5036559071 @default.
• W1989262521 hasAuthorship W1989262521A5036792360 @default.
• W1989262521 hasAuthorship W1989262521A5091743543 @default.
• W1989262521 hasBestOaLocation W19892625212 @default.
• W1989262521 hasConcept C126322002 @default.
• W1989262521 hasConcept C134018914 @default.
• W1989262521 hasConcept C147789679 @default.
• W1989262521 hasConcept C185592680 @default.
• W1989262521 hasConcept C2776125364 @default.
• W1989262521 hasConcept C2776420369 @default.
• W1989262521 hasConcept C2778063415 @default.
• W1989262521 hasConcept C2778553927 @default.
• W1989262521 hasConcept C2779246250 @default.
• W1989262521 hasConcept C2779764123 @default.
• W1989262521 hasConcept C2779978075 @default.
• W1989262521 hasConcept C2781112554 @default.

• next