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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989285918> ?p ?o ?g. }

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• W1989285918 abstract "The non‐steroidal anti‐inflammatory drug (NSAID) benoxaprofen at concentrations of 15, 30 and 60 μg ml −1 caused a dose‐related activation of superoxide generation by human polymorphonuclear leucocytes (PMNL) in vitro. The protein kinase C (PKC) inhibitor H‐7 prevented benoxaprofen‐mediated activation of superoxide generation by PMNL. Benoxaprofen, by apparent substitution for phosphatidylserine, caused a dose‐related activation of purified PKC from rat brain and in cytosolic extracts from human platelets. Benoxaprofen‐mediated stimulation of PMNL membrane‐associated oxidative metabolism is due to apparent activation of PKC by this NSAID. These findings establish the molecular basis of the pro‐oxidative properties of benoxaprofen." @default.
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• W1989285918 date "1988-02-01" @default.
• W1989285918 modified "2023-10-18" @default.
• W1989285918 title "Benoxaprofen activates membrane-associated oxidative metabolism in human polymorphonuclear leucocytes by apparent modulation of protein kinase C" @default.
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• W1989285918 doi "https://doi.org/10.1111/j.1476-5381.1988.tb11433.x" @default.
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