FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989287789> ?p ?o ?g. }

• W1989287789 endingPage "27" @default.
• W1989287789 startingPage "18" @default.
• W1989287789 abstract "Studies were undertaken to examine the mechanism whereby changes in intraluminal flow rates after reabsorption in the isolated perfused proximal tubule of the rabbit. All protocols employed the technique of in vitro perfusion of isolated segments of the proximal convoluted tubule. Stepwise elimination of d-glucose and l-alanine from an artifical perfusate stimulating ultrafiltrate decreased the unidirectional flux of sodium, transtubular potential difference, and net water absorption. Using isosmolal ultrafiltrate as the perfusate, net fluid reabsorption and the unidirectional lumen-to-bath flux of sodium and chloride decreased with a decrease in flow rate below 11 nl/min, but neither net fluid reabsorption nor the unidirectional fluxes of sodium and chloride increased further as the perfusion rate was increased above 11 nl/min. The unidirectional flux of 14C-urea was not affected by changes of perfusion rate from 1.6 to 44 nl/min. The dependence of net fluid reabsorption and unidirectional fluxes of sodium and chloride on flow rate per se, and not on intraluminal hydrostatic pressure or geometry, was established by demonstrating their decrease despite a rise in intraluminal pressure and inside diameter produced by counterpressure at the collecting end of the tubule, while flow was decreased. Ouabain decreased net fluid reabsorption to near zero at all flow rates, but ouabain had no effect on the flow-dependency of unidirectional sodium anf sodium was eliminated with a decrease in bicarbonate concentration and removal of d-glucose and l-alanine from the perfusate. Thus, the present studies demonstrate that net water and unidirectional sodium and chloride fluxes are flow-dependent. At flow rates somewhere below 11 nl/min, unidirectional fluxes decreased with decreasing perfusion rates; however, at perfusion rates greater than 11 nl/min, there was no further effect of perfusion rate on either net water absorption or the unidirectional fluxes of sodium or chloride. These effects may be partly mediated through the flow-dependent changes in the intraluminal concentration of bicarbonate, d-glucose, and 1-alanine." @default.
• W1989287789 created "2016-06-24" @default.
• W1989287789 creator A5012536115 @default.
• W1989287789 creator A5017590178 @default.
• W1989287789 creator A5067129683 @default.
• W1989287789 date "1977-01-01" @default.
• W1989287789 modified "2023-10-15" @default.
• W1989287789 title "Effect of perfusion rate on the fluxes of water, sodium, chloride and urea across the proximal convoluted tubule" @default.
• W1989287789 cites W1965462679 @default.
• W1989287789 cites W1985918799 @default.
• W1989287789 cites W1995628782 @default.
• W1989287789 cites W2006047685 @default.
• W1989287789 cites W2027360950 @default.
• W1989287789 cites W2034174971 @default.
• W1989287789 cites W2034480110 @default.
• W1989287789 cites W2037991530 @default.
• W1989287789 cites W2042560530 @default.
• W1989287789 cites W2048040531 @default.
• W1989287789 cites W2075094551 @default.
• W1989287789 cites W2128599513 @default.
• W1989287789 cites W2130933873 @default.
• W1989287789 cites W2356576063 @default.
• W1989287789 cites W2397379487 @default.
• W1989287789 cites W2402692181 @default.
• W1989287789 cites W2419616041 @default.
• W1989287789 cites W2432801727 @default.
• W1989287789 cites W2463188126 @default.
• W1989287789 cites W2475340699 @default.
• W1989287789 cites W87977281 @default.
• W1989287789 doi "https://doi.org/10.1038/ki.1977.3" @default.
• W1989287789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/839650" @default.
• W1989287789 hasPublicationYear "1977" @default.
• W1989287789 type Work @default.
• W1989287789 sameAs 1989287789 @default.
• W1989287789 citedByCount "35" @default.
• W1989287789 countsByYear W19892877892020 @default.
• W1989287789 countsByYear W19892877892022 @default.
• W1989287789 crossrefType "journal-article" @default.
• W1989287789 hasAuthorship W1989287789A5012536115 @default.
• W1989287789 hasAuthorship W1989287789A5017590178 @default.
• W1989287789 hasAuthorship W1989287789A5067129683 @default.
• W1989287789 hasBestOaLocation W19892877891 @default.
• W1989287789 hasConcept C121332964 @default.
• W1989287789 hasConcept C126322002 @default.
• W1989287789 hasConcept C134018914 @default.
• W1989287789 hasConcept C146957229 @default.
• W1989287789 hasConcept C178790620 @default.
• W1989287789 hasConcept C185592680 @default.
• W1989287789 hasConcept C2778437025 @default.
• W1989287789 hasConcept C2779010597 @default.
• W1989287789 hasConcept C2779133857 @default.
• W1989287789 hasConcept C2780091579 @default.
• W1989287789 hasConcept C2780365088 @default.
• W1989287789 hasConcept C2780498532 @default.
• W1989287789 hasConcept C28938303 @default.
• W1989287789 hasConcept C2910081258 @default.
• W1989287789 hasConcept C41625074 @default.
• W1989287789 hasConcept C537181965 @default.
• W1989287789 hasConcept C55493867 @default.
• W1989287789 hasConcept C56906281 @default.
• W1989287789 hasConcept C57476199 @default.
• W1989287789 hasConcept C71924100 @default.
• W1989287789 hasConcept C86803240 @default.
• W1989287789 hasConcept C97355855 @default.
• W1989287789 hasConcept C99975950 @default.
• W1989287789 hasConceptScore W1989287789C121332964 @default.
• W1989287789 hasConceptScore W1989287789C126322002 @default.
• W1989287789 hasConceptScore W1989287789C134018914 @default.
• W1989287789 hasConceptScore W1989287789C146957229 @default.
• W1989287789 hasConceptScore W1989287789C178790620 @default.
• W1989287789 hasConceptScore W1989287789C185592680 @default.
• W1989287789 hasConceptScore W1989287789C2778437025 @default.
• W1989287789 hasConceptScore W1989287789C2779010597 @default.
• W1989287789 hasConceptScore W1989287789C2779133857 @default.
• W1989287789 hasConceptScore W1989287789C2780091579 @default.
• W1989287789 hasConceptScore W1989287789C2780365088 @default.
• W1989287789 hasConceptScore W1989287789C2780498532 @default.
• W1989287789 hasConceptScore W1989287789C28938303 @default.
• W1989287789 hasConceptScore W1989287789C2910081258 @default.
• W1989287789 hasConceptScore W1989287789C41625074 @default.
• W1989287789 hasConceptScore W1989287789C537181965 @default.
• W1989287789 hasConceptScore W1989287789C55493867 @default.
• W1989287789 hasConceptScore W1989287789C56906281 @default.
• W1989287789 hasConceptScore W1989287789C57476199 @default.
• W1989287789 hasConceptScore W1989287789C71924100 @default.
• W1989287789 hasConceptScore W1989287789C86803240 @default.
• W1989287789 hasConceptScore W1989287789C97355855 @default.
• W1989287789 hasConceptScore W1989287789C99975950 @default.
• W1989287789 hasIssue "1" @default.
• W1989287789 hasLocation W19892877891 @default.
• W1989287789 hasLocation W19892877892 @default.
• W1989287789 hasOpenAccess W1989287789 @default.
• W1989287789 hasPrimaryLocation W19892877891 @default.
• W1989287789 hasRelatedWork W1965591807 @default.
• W1989287789 hasRelatedWork W1993413886 @default.
• W1989287789 hasRelatedWork W2029671730 @default.
• W1989287789 hasRelatedWork W2075094551 @default.
• W1989287789 hasRelatedWork W2085164884 @default.

• next