Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989291201> ?p ?o ?g. }
- W1989291201 endingPage "849" @default.
- W1989291201 startingPage "843" @default.
- W1989291201 abstract "When disengaged interactions within a receptor are turned on by its guest, these intrahost interactions will contribute to the overall binding energy. Although such receptors are common in biology, their synthetic mimics are rare and difficult to design. By engineering conflictory requirements between intrareceptor electrostatic and hydrophobic interactions, we enabled complementary guests to eliminate the “electrostatic frustration” within the host and turn on the intrahost interactions. The result was a binding constant of Ka >105 M–1 from ammonium–carboxylate salt bridges that typically function poorly in water. These cooperatively enhanced receptors displayed excellent selectivity in binding, despite a large degree of conformational flexibility in the structure." @default.
- W1989291201 created "2016-06-24" @default.
- W1989291201 creator A5011668280 @default.
- W1989291201 creator A5023367767 @default.
- W1989291201 date "2015-01-06" @default.
- W1989291201 modified "2023-10-03" @default.
- W1989291201 title "Rationally Designed Cooperatively Enhanced Receptors To Magnify Host–Guest Binding in Water" @default.
- W1989291201 cites W1963740321 @default.
- W1989291201 cites W1966545431 @default.
- W1989291201 cites W1969359875 @default.
- W1989291201 cites W1979426884 @default.
- W1989291201 cites W1983047899 @default.
- W1989291201 cites W1983838648 @default.
- W1989291201 cites W1986025973 @default.
- W1989291201 cites W1990886085 @default.
- W1989291201 cites W1993533895 @default.
- W1989291201 cites W1997158083 @default.
- W1989291201 cites W2004056158 @default.
- W1989291201 cites W2006076939 @default.
- W1989291201 cites W2009071379 @default.
- W1989291201 cites W2013268943 @default.
- W1989291201 cites W2016384435 @default.
- W1989291201 cites W2024794609 @default.
- W1989291201 cites W2030408946 @default.
- W1989291201 cites W2037849444 @default.
- W1989291201 cites W2042584758 @default.
- W1989291201 cites W2045861800 @default.
- W1989291201 cites W2048631643 @default.
- W1989291201 cites W2048989570 @default.
- W1989291201 cites W2050694122 @default.
- W1989291201 cites W2059615538 @default.
- W1989291201 cites W2061469445 @default.
- W1989291201 cites W2072133631 @default.
- W1989291201 cites W2074210926 @default.
- W1989291201 cites W2077839705 @default.
- W1989291201 cites W2086054462 @default.
- W1989291201 cites W2086180379 @default.
- W1989291201 cites W2086506282 @default.
- W1989291201 cites W2087871271 @default.
- W1989291201 cites W2092139560 @default.
- W1989291201 cites W2092709309 @default.
- W1989291201 cites W2097855505 @default.
- W1989291201 cites W2098376669 @default.
- W1989291201 cites W2117384307 @default.
- W1989291201 cites W2129856353 @default.
- W1989291201 cites W2133591126 @default.
- W1989291201 cites W2134229410 @default.
- W1989291201 cites W2140170994 @default.
- W1989291201 cites W2142937972 @default.
- W1989291201 cites W2148284816 @default.
- W1989291201 cites W2152380893 @default.
- W1989291201 cites W2164050728 @default.
- W1989291201 cites W2169594520 @default.
- W1989291201 cites W2170402416 @default.
- W1989291201 cites W2313688730 @default.
- W1989291201 cites W2319351032 @default.
- W1989291201 cites W2949611276 @default.
- W1989291201 cites W2952536356 @default.
- W1989291201 cites W3005435921 @default.
- W1989291201 cites W4252604579 @default.
- W1989291201 doi "https://doi.org/10.1021/ja510823h" @default.
- W1989291201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25531747" @default.
- W1989291201 hasPublicationYear "2015" @default.
- W1989291201 type Work @default.
- W1989291201 sameAs 1989291201 @default.
- W1989291201 citedByCount "25" @default.
- W1989291201 countsByYear W19892912012015 @default.
- W1989291201 countsByYear W19892912012016 @default.
- W1989291201 countsByYear W19892912012017 @default.
- W1989291201 countsByYear W19892912012018 @default.
- W1989291201 countsByYear W19892912012020 @default.
- W1989291201 countsByYear W19892912012022 @default.
- W1989291201 crossrefType "journal-article" @default.
- W1989291201 hasAuthorship W1989291201A5011668280 @default.
- W1989291201 hasAuthorship W1989291201A5023367767 @default.
- W1989291201 hasBestOaLocation W19892912012 @default.
- W1989291201 hasConcept C105795698 @default.
- W1989291201 hasConcept C107824862 @default.
- W1989291201 hasConcept C118792377 @default.
- W1989291201 hasConcept C12554922 @default.
- W1989291201 hasConcept C126831891 @default.
- W1989291201 hasConcept C14036430 @default.
- W1989291201 hasConcept C15920480 @default.
- W1989291201 hasConcept C161790260 @default.
- W1989291201 hasConcept C170493617 @default.
- W1989291201 hasConcept C178790620 @default.
- W1989291201 hasConcept C185592680 @default.
- W1989291201 hasConcept C18903297 @default.
- W1989291201 hasConcept C2778074193 @default.
- W1989291201 hasConcept C2780598303 @default.
- W1989291201 hasConcept C33923547 @default.
- W1989291201 hasConcept C521977710 @default.
- W1989291201 hasConcept C55493867 @default.
- W1989291201 hasConcept C67407626 @default.
- W1989291201 hasConcept C71240020 @default.
- W1989291201 hasConcept C86803240 @default.
- W1989291201 hasConcept C90260826 @default.
- W1989291201 hasConcept C95444343 @default.