Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989300385> ?p ?o ?g. }
- W1989300385 endingPage "109" @default.
- W1989300385 startingPage "99" @default.
- W1989300385 abstract "In allogeneic hematopoietic stem cell transplantation (AHSCT) graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effect are closely but not invariably linked. Thus, harnessing donor lymphocyte mediated GVL immunity and separating it from GVHD is of particular interest. Based on results obtained in murine models we have explored the CD95-mediated activation-induced cell death (AICD) strategy to selectively deplete alloreactivity in human donor T lymphocytes in vitro. Following stimulation of CD3(+) T cells isolated from HLA-A* 0201-positive donors with HLA or minor histocompatibility antigen mismatched hematopoietic or nonhematopoietic cells in the presence of agonistic anti-CD95 antibody, we achieved efficient and selective allodepletion across major and minor histocompatibility mismatched barriers. Residual alloreactivity was in the range of 10% and 25% using hematopoietic cells and primary keratinocytes as alloantigen-presenting cells, respectively. CD8(+) T cells specific for HLA-A * 0201-associated cytomegalovirus (CMV), Epstein-Barr virus (EBV), and Wilms tumor 1 peptide epitopes were retained at significant numbers within the allodepleted donor lymphocyte subsets. Additionally, CD4(+) FoxP3(+) regulatory T cells persisted after the allodepletion procedure. Our results show that AICD induced by an agonistic anti-CD95 antibody might be useful to generate allodepleted donor lymphocyte products with preserved beneficial immune functions for patients undergoing AHSCT." @default.
- W1989300385 created "2016-06-24" @default.
- W1989300385 creator A5036175709 @default.
- W1989300385 creator A5040663053 @default.
- W1989300385 creator A5043289972 @default.
- W1989300385 creator A5050892882 @default.
- W1989300385 creator A5070448202 @default.
- W1989300385 creator A5074754127 @default.
- W1989300385 date "2008-01-01" @default.
- W1989300385 modified "2023-10-16" @default.
- W1989300385 title "Depletion of Alloreactive Donor T Lymphocytes by CD95-Mediated Activation-Induced Cell Death Retains Antileukemic, Antiviral, and Immunoregulatory T Cell Immunity" @default.
- W1989300385 cites W1274344746 @default.
- W1989300385 cites W1545991364 @default.
- W1989300385 cites W1560277370 @default.
- W1989300385 cites W159030646 @default.
- W1989300385 cites W1608965220 @default.
- W1989300385 cites W1977209916 @default.
- W1989300385 cites W1981122272 @default.
- W1989300385 cites W1983858501 @default.
- W1989300385 cites W1986374907 @default.
- W1989300385 cites W1991511096 @default.
- W1989300385 cites W1999827974 @default.
- W1989300385 cites W2002726823 @default.
- W1989300385 cites W2009607549 @default.
- W1989300385 cites W2012379095 @default.
- W1989300385 cites W2013425867 @default.
- W1989300385 cites W2014888025 @default.
- W1989300385 cites W2023858907 @default.
- W1989300385 cites W2026734902 @default.
- W1989300385 cites W2027582676 @default.
- W1989300385 cites W2028475115 @default.
- W1989300385 cites W2041027155 @default.
- W1989300385 cites W2042952613 @default.
- W1989300385 cites W2042961427 @default.
- W1989300385 cites W2047511312 @default.
- W1989300385 cites W2058026156 @default.
- W1989300385 cites W2058053814 @default.
- W1989300385 cites W2063142731 @default.
- W1989300385 cites W2064252284 @default.
- W1989300385 cites W2082603557 @default.
- W1989300385 cites W2085530853 @default.
- W1989300385 cites W2095466773 @default.
- W1989300385 cites W2095739043 @default.
- W1989300385 cites W2098254750 @default.
- W1989300385 cites W2104294740 @default.
- W1989300385 cites W2105079905 @default.
- W1989300385 cites W2110252464 @default.
- W1989300385 cites W2112041130 @default.
- W1989300385 cites W2129971278 @default.
- W1989300385 cites W2149936872 @default.
- W1989300385 cites W2154896319 @default.
- W1989300385 cites W2157325100 @default.
- W1989300385 cites W2167541030 @default.
- W1989300385 cites W2262568580 @default.
- W1989300385 cites W2334996664 @default.
- W1989300385 cites W2336061803 @default.
- W1989300385 cites W44995847 @default.
- W1989300385 doi "https://doi.org/10.1016/j.bbmt.2007.10.002" @default.
- W1989300385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18158966" @default.
- W1989300385 hasPublicationYear "2008" @default.
- W1989300385 type Work @default.
- W1989300385 sameAs 1989300385 @default.
- W1989300385 citedByCount "33" @default.
- W1989300385 countsByYear W19893003852013 @default.
- W1989300385 countsByYear W19893003852014 @default.
- W1989300385 countsByYear W19893003852015 @default.
- W1989300385 countsByYear W19893003852017 @default.
- W1989300385 countsByYear W19893003852020 @default.
- W1989300385 countsByYear W19893003852021 @default.
- W1989300385 crossrefType "journal-article" @default.
- W1989300385 hasAuthorship W1989300385A5036175709 @default.
- W1989300385 hasAuthorship W1989300385A5040663053 @default.
- W1989300385 hasAuthorship W1989300385A5043289972 @default.
- W1989300385 hasAuthorship W1989300385A5050892882 @default.
- W1989300385 hasAuthorship W1989300385A5070448202 @default.
- W1989300385 hasAuthorship W1989300385A5074754127 @default.
- W1989300385 hasBestOaLocation W19893003851 @default.
- W1989300385 hasConcept C126322002 @default.
- W1989300385 hasConcept C147483822 @default.
- W1989300385 hasConcept C154317977 @default.
- W1989300385 hasConcept C167672396 @default.
- W1989300385 hasConcept C202751555 @default.
- W1989300385 hasConcept C203014093 @default.
- W1989300385 hasConcept C2776090121 @default.
- W1989300385 hasConcept C2779695342 @default.
- W1989300385 hasConcept C2779972918 @default.
- W1989300385 hasConcept C2911091166 @default.
- W1989300385 hasConcept C55493867 @default.
- W1989300385 hasConcept C71924100 @default.
- W1989300385 hasConcept C86803240 @default.
- W1989300385 hasConcept C8891405 @default.
- W1989300385 hasConceptScore W1989300385C126322002 @default.
- W1989300385 hasConceptScore W1989300385C147483822 @default.
- W1989300385 hasConceptScore W1989300385C154317977 @default.
- W1989300385 hasConceptScore W1989300385C167672396 @default.
- W1989300385 hasConceptScore W1989300385C202751555 @default.
- W1989300385 hasConceptScore W1989300385C203014093 @default.
- W1989300385 hasConceptScore W1989300385C2776090121 @default.