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• W1989307265 abstract "Virologic and immunologic responses were examined for 33 human immunodeficiency virus (HIV)-infected children who participated for > or = 96 weeks in a phase 1/2 protocol of 16 weeks of indinavir monotherapy, followed by the addition of zidovudine and lamivudine. At week 96, a median increase of 199 CD4+ T cells/microL and a median decrease of 0.74 log(10) HIV RNA copies/mL were observed. The relationship between control of viral replication and CD4) T cell count was examined. Patients were categorized into 3 response groups on the basis of duration and extent of control of viral replication. Of 21 children with a transient decrease in virus load of > or = 0.7 log(10) HIV RNA copies/mL from baseline, 7 experienced sustained increases in CD4+, CD4+ CD45RA+, and CD4+ CD45RO+ T cell counts. CD4+ CD45RA+ (naive) T cells were the major contributor to CD4+ T cell expansion. Continued long-term immunologic benefit may be experienced by a subset of children, despite only transient virologic suppression." @default.
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• W1989307265 date "2001-04-01" @default.
• W1989307265 modified "2023-09-23" @default.
• W1989307265 title "Long‐term Virologic and Immunologic Responses in Human Immunodeficiency Virus Type 1–Infected Children Treated with Indinavir, Zidovudine, and Lamivudine" @default.
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• W1989307265 doi "https://doi.org/10.1086/319274" @default.
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