FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989323017> ?p ?o ?g. }

• W1989323017 endingPage "10161" @default.
• W1989323017 startingPage "10146" @default.
• W1989323017 abstract "Sinulariolide, an active compound isolated from the cultured soft coral Sinularia flexibilis, has potent anti-microbial and anti-tumorigenesis effects towards melanoma and bladder cancer cells. In this study, we investigated the effects of sinulariolide on hepatocellular carcinoma (HCC) cell growth and protein expression. Sinulariolide suppressed the proliferation and colony formation of HCC HA22T cells in a dose-dependent manner and induced both early and late apoptosis according to flow cytometry, Annexin V/PI stain and TUNEL/DAPI stain analyses. A mechanistic analysis demonstrated that sinulariolide-induced apoptosis was activated through a mitochondria-related pathway, showing up-regulation of Bax, Bad and AIF, and down- regulation of Bcl-2, Bcl-xL, MCl-1 and p-Bad. Sinulariolide treatment led to loss of the mitochondrial membrane potential, release of mitochondrial cytochrome c to the cytosol, and activation of both caspase-9 and caspase-3. Sinulariolide-induced apoptosis was significantly blocked by the caspase inhibitors Z-VAD-FMK and Z-DEVD-FMK. The increased expression of cleaved PARP also suggested that caspase-independent apoptotic pathway was involved. In the western blotting; the elevation of ER chaperones GRP78; GRP94; and CALR; as well as up-regulations of PERK/eIF2α/ATF4/CHOP; and diminished cell death with pre-treatment of eIF2α phosphatase inhibitor; salubrinal; implicated the involvement of ER stress-mediated PERK/eIF2α/ATF4/CHOP apoptotic pathway following sinulariolide treatment in hepatoma cells. The current study suggested sinulariolide-induced hepatoma cell cytotoxicity involved multiple apoptotic signal pathways. This may implicate that sinulariolide is a potential compound for the treatment of hepatocellular carcinoma." @default.
• W1989323017 created "2016-06-24" @default.
• W1989323017 creator A5006635938 @default.
• W1989323017 creator A5022997140 @default.
• W1989323017 creator A5024520505 @default.
• W1989323017 creator A5032230796 @default.
• W1989323017 creator A5038121854 @default.
• W1989323017 creator A5046206259 @default.
• W1989323017 creator A5050382719 @default.
• W1989323017 creator A5055305461 @default.
• W1989323017 creator A5073269098 @default.
• W1989323017 creator A5079145162 @default.
• W1989323017 creator A5081613521 @default.
• W1989323017 creator A5089681726 @default.
• W1989323017 date "2013-08-22" @default.
• W1989323017 modified "2023-10-01" @default.
• W1989323017 title "Sinulariolide Induced Hepatocellular Carcinoma Apoptosis through Activation of Mitochondrial-Related Apoptotic and PERK/eIF2α/ATF4/CHOP Pathway" @default.
• W1989323017 cites W1501516610 @default.
• W1989323017 cites W1584611737 @default.
• W1989323017 cites W1600417207 @default.
• W1989323017 cites W188097045 @default.
• W1989323017 cites W1967832687 @default.
• W1989323017 cites W1976161806 @default.
• W1989323017 cites W1977007459 @default.
• W1989323017 cites W1977436769 @default.
• W1989323017 cites W1977817230 @default.
• W1989323017 cites W1988777405 @default.
• W1989323017 cites W1991958238 @default.
• W1989323017 cites W1992319922 @default.
• W1989323017 cites W1994978451 @default.
• W1989323017 cites W2015635047 @default.
• W1989323017 cites W2020830322 @default.
• W1989323017 cites W2025511820 @default.
• W1989323017 cites W2027727753 @default.
• W1989323017 cites W2031735388 @default.
• W1989323017 cites W2070827783 @default.
• W1989323017 cites W2072378485 @default.
• W1989323017 cites W2089198803 @default.
• W1989323017 cites W2111683347 @default.
• W1989323017 cites W2112286580 @default.
• W1989323017 cites W2113999599 @default.
• W1989323017 cites W2122099135 @default.
• W1989323017 cites W2132369583 @default.
• W1989323017 cites W2133644385 @default.
• W1989323017 cites W2137052325 @default.
• W1989323017 cites W2140487984 @default.
• W1989323017 cites W2149067762 @default.
• W1989323017 cites W2159164794 @default.
• W1989323017 doi "https://doi.org/10.3390/molecules180910146" @default.
• W1989323017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6270604" @default.
• W1989323017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23973991" @default.
• W1989323017 hasPublicationYear "2013" @default.
• W1989323017 type Work @default.
• W1989323017 sameAs 1989323017 @default.
• W1989323017 citedByCount "42" @default.
• W1989323017 countsByYear W19893230172014 @default.
• W1989323017 countsByYear W19893230172015 @default.
• W1989323017 countsByYear W19893230172016 @default.
• W1989323017 countsByYear W19893230172017 @default.
• W1989323017 countsByYear W19893230172018 @default.
• W1989323017 countsByYear W19893230172019 @default.
• W1989323017 countsByYear W19893230172020 @default.
• W1989323017 countsByYear W19893230172021 @default.
• W1989323017 countsByYear W19893230172023 @default.
• W1989323017 crossrefType "journal-article" @default.
• W1989323017 hasAuthorship W1989323017A5006635938 @default.
• W1989323017 hasAuthorship W1989323017A5022997140 @default.
• W1989323017 hasAuthorship W1989323017A5024520505 @default.
• W1989323017 hasAuthorship W1989323017A5032230796 @default.
• W1989323017 hasAuthorship W1989323017A5038121854 @default.
• W1989323017 hasAuthorship W1989323017A5046206259 @default.
• W1989323017 hasAuthorship W1989323017A5050382719 @default.
• W1989323017 hasAuthorship W1989323017A5055305461 @default.
• W1989323017 hasAuthorship W1989323017A5073269098 @default.
• W1989323017 hasAuthorship W1989323017A5079145162 @default.
• W1989323017 hasAuthorship W1989323017A5081613521 @default.
• W1989323017 hasAuthorship W1989323017A5089681726 @default.
• W1989323017 hasBestOaLocation W19893230171 @default.
• W1989323017 hasConcept C139447449 @default.
• W1989323017 hasConcept C153911025 @default.
• W1989323017 hasConcept C163421366 @default.
• W1989323017 hasConcept C190283241 @default.
• W1989323017 hasConcept C2777527632 @default.
• W1989323017 hasConcept C29311851 @default.
• W1989323017 hasConcept C31573885 @default.
• W1989323017 hasConcept C502942594 @default.
• W1989323017 hasConcept C55493867 @default.
• W1989323017 hasConcept C86803240 @default.
• W1989323017 hasConcept C95444343 @default.
• W1989323017 hasConcept C98424977 @default.
• W1989323017 hasConceptScore W1989323017C139447449 @default.
• W1989323017 hasConceptScore W1989323017C153911025 @default.
• W1989323017 hasConceptScore W1989323017C163421366 @default.
• W1989323017 hasConceptScore W1989323017C190283241 @default.
• W1989323017 hasConceptScore W1989323017C2777527632 @default.
• W1989323017 hasConceptScore W1989323017C29311851 @default.
• W1989323017 hasConceptScore W1989323017C31573885 @default.
• W1989323017 hasConceptScore W1989323017C502942594 @default.

• next