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• W1989336946 endingPage "960" @default.
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• W1989336946 abstract "The hypothalamic-pituitary-thyroid (HPT) axis functions abnormally in man and animals chronically exposed to ethanol. The most consistent observation in humans is that the thyrotropin response to thyrotropin-releasing hormone (TRH) is blunted. We have tested the hypothesis that chronic ethanol treatment in rats leads to a diminished responsiveness of the hypothalamus to central stimulation. Animals were maintained on 1 of 3 diets for 4 weeks: (1) laboratory chow and water provided ad libitum (chow-fed), (2) Sustacal chocolate liquid diet with vitamin mixture containing 5% (w/v) ethanol provided ad libitum (ethanol), or (3) Sustacal chocolate liquid diet with vitamin mixture containing sucrose substituted isocalorically (35%) for ethanol and provided in amounts matched to a weight-paired, ethanol-treated animal (pair-fed). At the end of 4 weeks, the animals were evaluated for their response to a single injection of ethanol (3 g/kg, ip) and/or exposure to 5 degrees C. Chronic ethanol treatment produced an increase in TRH mRNA in neurons of the paraventricular nucleus and fully blocked the thyrotropic response to cold exposure. However, chronic ethanol-treated animals did not exhibit altered basal levels of triiodothyronine or thyrotropin, nor did they have an altered response to a single injection of ethanol. These data demonstrate that chronic alcohol exposure alters functioning of the hypothalamic-pituitary-thyroid axis at least in part by affecting TRH neurons of the paraventricular nucleus." @default.
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• W1989336946 date "1996-08-01" @default.
• W1989336946 modified "2023-09-27" @default.
• W1989336946 title "Chronic Ethanol Treatment Reduces the Responsiveness of the Hypothalamic-Pituitary-Thyroid Axis to Central Stimulation" @default.
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• W1989336946 doi "https://doi.org/10.1111/j.1530-0277.1996.tb05277.x" @default.
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