FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989348523> ?p ?o ?g. }

• W1989348523 endingPage "927" @default.
• W1989348523 startingPage "915" @default.
• W1989348523 abstract "The pathogenesis of cystic fibrosis (CF) airway disease is not well understood. A porcine CF model was recently generated, and these animals develop lung disease similar to humans with CF. At birth, before infection and inflammation, CF pigs have airways that are irregularly shaped and have a reduced caliber compared to non-CF pigs. We hypothesized that these airway structural abnormalities affect airflow patterns and particle distribution. To test this hypothesis we used computational fluid dynamics (CFD) on airway geometries obtained by computed tomography of newborn non-CF and CF pigs. For the same flow rate, newborn CF pig airways exhibited higher air velocity and resistance compared to non-CF. Moreover we found that, at the carina bifurcation, particles greater than 5-μm preferably distributed to the right CF lung despite almost equal airflow ventilation in non-CF and CF. CFD modeling also predicted that deposition efficiency was greater in CF compared to non-CF for 5- and 10-μm particles. These differences were most significant in the airways included in the geometry supplying the right caudal, right accessory, left caudal, and left cranial lobes. The irregular particle distribution and increased deposition in newborn CF pig airways suggest that early airway structural abnormalities might contribute to CF disease pathogenesis." @default.
• W1989348523 created "2016-06-24" @default.
• W1989348523 creator A5006854308 @default.
• W1989348523 creator A5011527598 @default.
• W1989348523 creator A5022422924 @default.
• W1989348523 creator A5030201846 @default.
• W1989348523 creator A5037476637 @default.
• W1989348523 creator A5041116309 @default.
• W1989348523 creator A5046834672 @default.
• W1989348523 creator A5050362266 @default.
• W1989348523 creator A5056413971 @default.
• W1989348523 creator A5059968622 @default.
• W1989348523 creator A5071272823 @default.
• W1989348523 date "2013-12-06" @default.
• W1989348523 modified "2023-10-10" @default.
• W1989348523 title "Early Airway Structural Changes in Cystic Fibrosis Pigs as a Determinant of Particle Distribution and Deposition" @default.
• W1989348523 cites W1720376487 @default.
• W1989348523 cites W1786021994 @default.
• W1989348523 cites W1969495999 @default.
• W1989348523 cites W1973280592 @default.
• W1989348523 cites W1983495472 @default.
• W1989348523 cites W1988988333 @default.
• W1989348523 cites W1989147478 @default.
• W1989348523 cites W1993234862 @default.
• W1989348523 cites W1999657318 @default.
• W1989348523 cites W2000224610 @default.
• W1989348523 cites W2006699864 @default.
• W1989348523 cites W2017939832 @default.
• W1989348523 cites W2023159816 @default.
• W1989348523 cites W2025018153 @default.
• W1989348523 cites W2030670821 @default.
• W1989348523 cites W2033784709 @default.
• W1989348523 cites W2037789035 @default.
• W1989348523 cites W2039462910 @default.
• W1989348523 cites W2040098422 @default.
• W1989348523 cites W2045776266 @default.
• W1989348523 cites W2053005903 @default.
• W1989348523 cites W2053407905 @default.
• W1989348523 cites W2055908462 @default.
• W1989348523 cites W2060085561 @default.
• W1989348523 cites W2062337093 @default.
• W1989348523 cites W2071424500 @default.
• W1989348523 cites W2073453899 @default.
• W1989348523 cites W2081979876 @default.
• W1989348523 cites W2083169368 @default.
• W1989348523 cites W2087326716 @default.
• W1989348523 cites W2087334060 @default.
• W1989348523 cites W2093963954 @default.
• W1989348523 cites W2094910682 @default.
• W1989348523 cites W2101026179 @default.
• W1989348523 cites W2107360941 @default.
• W1989348523 cites W2126052517 @default.
• W1989348523 cites W2130231206 @default.
• W1989348523 cites W2154466524 @default.
• W1989348523 cites W2167811134 @default.
• W1989348523 cites W2172012864 @default.
• W1989348523 cites W2179787356 @default.
• W1989348523 cites W4241884576 @default.
• W1989348523 cites W4254409527 @default.
• W1989348523 doi "https://doi.org/10.1007/s10439-013-0955-7" @default.
• W1989348523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3954455" @default.
• W1989348523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24310865" @default.
• W1989348523 hasPublicationYear "2013" @default.
• W1989348523 type Work @default.
• W1989348523 sameAs 1989348523 @default.
• W1989348523 citedByCount "23" @default.
• W1989348523 countsByYear W19893485232015 @default.
• W1989348523 countsByYear W19893485232016 @default.
• W1989348523 countsByYear W19893485232017 @default.
• W1989348523 countsByYear W19893485232018 @default.
• W1989348523 countsByYear W19893485232019 @default.
• W1989348523 countsByYear W19893485232020 @default.
• W1989348523 countsByYear W19893485232021 @default.
• W1989348523 countsByYear W19893485232022 @default.
• W1989348523 crossrefType "journal-article" @default.
• W1989348523 hasAuthorship W1989348523A5006854308 @default.
• W1989348523 hasAuthorship W1989348523A5011527598 @default.
• W1989348523 hasAuthorship W1989348523A5022422924 @default.
• W1989348523 hasAuthorship W1989348523A5030201846 @default.
• W1989348523 hasAuthorship W1989348523A5037476637 @default.
• W1989348523 hasAuthorship W1989348523A5041116309 @default.
• W1989348523 hasAuthorship W1989348523A5046834672 @default.
• W1989348523 hasAuthorship W1989348523A5050362266 @default.
• W1989348523 hasAuthorship W1989348523A5056413971 @default.
• W1989348523 hasAuthorship W1989348523A5059968622 @default.
• W1989348523 hasAuthorship W1989348523A5071272823 @default.
• W1989348523 hasBestOaLocation W19893485232 @default.
• W1989348523 hasConcept C105922876 @default.
• W1989348523 hasConcept C110121322 @default.
• W1989348523 hasConcept C121332964 @default.
• W1989348523 hasConcept C126322002 @default.
• W1989348523 hasConcept C134306372 @default.
• W1989348523 hasConcept C141071460 @default.
• W1989348523 hasConcept C142724271 @default.
• W1989348523 hasConcept C178790620 @default.
• W1989348523 hasConcept C185592680 @default.
• W1989348523 hasConcept C200457457 @default.
• W1989348523 hasConcept C2776938444 @default.

• next