Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989348548> ?p ?o ?g. }
- W1989348548 endingPage "027109" @default.
- W1989348548 startingPage "027109" @default.
- W1989348548 abstract "Lung cancer is the leading cause of cancer deaths. Unfortunately, lung cancer is often diagnosed only when it becomes symptomatic or at an advanced stage when few treatment options are available. Hence, a diagnostic test suitable for screening widespread populations is required to enable earlier diagnosis. Analysis of exhaled breath provides a non-invasive method for early detection of lung cancer. Analysis of volatile organic compounds (VOCs) by various mass spectral techniques has identified potential biomarkers of disease. Nevertheless, the metabolic origins and the disease specificity of VOCs need further elucidation. Cell culture metabolomics can be used as a bottom-up approach to identify biomarkers of pathological conditions and can also be used to study the metabolic pathways that produce such compounds. This paper summarizes the current knowledge of lung cancer biomarkers in exhaled breath and emphasizes the critical role of cell culture conditions in determining the VOCs produced in vitro. Hypoxic culture conditions more closely mimic the conditions of cancer cell growth in vivo. We propose that since hypoxia influences cell metabolism and so potentially the VOCs that the cancer cells produce, the cell culture metabolomics projects should consider culturing cancer cells in hypoxic conditions." @default.
- W1989348548 created "2016-06-24" @default.
- W1989348548 creator A5027953825 @default.
- W1989348548 creator A5048434377 @default.
- W1989348548 creator A5085304042 @default.
- W1989348548 date "2014-05-27" @default.
- W1989348548 modified "2023-09-27" @default.
- W1989348548 title "Cell culture metabolomics in the diagnosis of lung cancer—the influence of cell culture conditions" @default.
- W1989348548 cites W1482076735 @default.
- W1989348548 cites W1493048246 @default.
- W1989348548 cites W1547961512 @default.
- W1989348548 cites W1659020806 @default.
- W1989348548 cites W1797956629 @default.
- W1989348548 cites W1892693836 @default.
- W1989348548 cites W1965473974 @default.
- W1989348548 cites W1967376028 @default.
- W1989348548 cites W1968813633 @default.
- W1989348548 cites W1970426869 @default.
- W1989348548 cites W1983199304 @default.
- W1989348548 cites W1983548993 @default.
- W1989348548 cites W1984409435 @default.
- W1989348548 cites W1990244063 @default.
- W1989348548 cites W2005943821 @default.
- W1989348548 cites W2007287727 @default.
- W1989348548 cites W2007635507 @default.
- W1989348548 cites W2007823368 @default.
- W1989348548 cites W2011810742 @default.
- W1989348548 cites W2017224356 @default.
- W1989348548 cites W2021741218 @default.
- W1989348548 cites W2023002358 @default.
- W1989348548 cites W2027705428 @default.
- W1989348548 cites W2030427239 @default.
- W1989348548 cites W2031342864 @default.
- W1989348548 cites W2032762248 @default.
- W1989348548 cites W2033958147 @default.
- W1989348548 cites W2036103055 @default.
- W1989348548 cites W2038145784 @default.
- W1989348548 cites W2048541209 @default.
- W1989348548 cites W2048885214 @default.
- W1989348548 cites W2050826644 @default.
- W1989348548 cites W2051309297 @default.
- W1989348548 cites W2054931962 @default.
- W1989348548 cites W2061084552 @default.
- W1989348548 cites W2063821826 @default.
- W1989348548 cites W2064065142 @default.
- W1989348548 cites W2070666438 @default.
- W1989348548 cites W2077217947 @default.
- W1989348548 cites W2081124556 @default.
- W1989348548 cites W2092496626 @default.
- W1989348548 cites W2099417786 @default.
- W1989348548 cites W2100266961 @default.
- W1989348548 cites W2102788947 @default.
- W1989348548 cites W2102960450 @default.
- W1989348548 cites W2104896299 @default.
- W1989348548 cites W2106982482 @default.
- W1989348548 cites W2109543726 @default.
- W1989348548 cites W2122931037 @default.
- W1989348548 cites W2126945850 @default.
- W1989348548 cites W2127501500 @default.
- W1989348548 cites W2135089223 @default.
- W1989348548 cites W2144208228 @default.
- W1989348548 cites W2145640842 @default.
- W1989348548 cites W2162434031 @default.
- W1989348548 cites W2168137245 @default.
- W1989348548 cites W4238215265 @default.
- W1989348548 cites W4239593130 @default.
- W1989348548 cites W4240461938 @default.
- W1989348548 doi "https://doi.org/10.1088/1752-7155/8/2/027109" @default.
- W1989348548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24861817" @default.
- W1989348548 hasPublicationYear "2014" @default.
- W1989348548 type Work @default.
- W1989348548 sameAs 1989348548 @default.
- W1989348548 citedByCount "38" @default.
- W1989348548 countsByYear W19893485482015 @default.
- W1989348548 countsByYear W19893485482016 @default.
- W1989348548 countsByYear W19893485482017 @default.
- W1989348548 countsByYear W19893485482018 @default.
- W1989348548 countsByYear W19893485482019 @default.
- W1989348548 countsByYear W19893485482020 @default.
- W1989348548 countsByYear W19893485482021 @default.
- W1989348548 countsByYear W19893485482022 @default.
- W1989348548 countsByYear W19893485482023 @default.
- W1989348548 crossrefType "journal-article" @default.
- W1989348548 hasAuthorship W1989348548A5027953825 @default.
- W1989348548 hasAuthorship W1989348548A5048434377 @default.
- W1989348548 hasAuthorship W1989348548A5085304042 @default.
- W1989348548 hasBestOaLocation W19893485481 @default.
- W1989348548 hasConcept C105702510 @default.
- W1989348548 hasConcept C121608353 @default.
- W1989348548 hasConcept C126322002 @default.
- W1989348548 hasConcept C142724271 @default.
- W1989348548 hasConcept C1491633281 @default.
- W1989348548 hasConcept C178790620 @default.
- W1989348548 hasConcept C185592680 @default.
- W1989348548 hasConcept C203014093 @default.
- W1989348548 hasConcept C21565614 @default.
- W1989348548 hasConcept C2776042228 @default.
- W1989348548 hasConcept C2776256026 @default.