Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989355943> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W1989355943 endingPage "11" @default.
- W1989355943 startingPage "5" @default.
- W1989355943 abstract "The functional relationship in vitro between mitogen-induced lymphocyte transformation, lymphocyte response to interleukin-2 (IL-2) and steroid, and production of IL-2 was examined in patients with chronic renal failure on hemodialysis (HD) or on continuous ambulatory peritoneal dialysis (CAPD). The lymphocyte responses to optimal stimulation with phytohemagglutinin, concanavalin A, and pokeweed mitogen were depressed in lymphocyte cultures from HD patients, while CAPD lymphocyte cultures responded normally. However, at suboptimal phytohemagglutinin stimulation both CAPD lymphocyte and HD lymphocyte responses were subnormal. Uremic lymphocyte cultures were more sensitive to the immunosuppressive effect of methylprednisolone. Addition of IL-2 normalized the phytohemagglutinin responses of suboptimally stimulated CAPD lymphocyte cultures and clearly improved the mitogen responses of the HD lymphocyte cultures. Furthermore, the increased uremic lymphocyte sensitivity to methylprednisolone was normalized by addition of IL-2 to the cultures. The measured IL-2 production had clearly decreased in the HD cultures after 48 h as compared to that of the control cultures. A similar but not significant trend was also seen in the CAPD cultures. Thus, it is suggested that a deficient production of IL-2 may partly explain the reduced lymphocyte response of uremic lymphocytes in vitro." @default.
- W1989355943 created "2016-06-24" @default.
- W1989355943 creator A5004078001 @default.
- W1989355943 creator A5059120671 @default.
- W1989355943 creator A5064301200 @default.
- W1989355943 date "1986-01-01" @default.
- W1989355943 modified "2023-09-25" @default.
- W1989355943 title "Effect of Interleukin-2 and Methylprednisolone on in vitro Transformation of Uremic Lymphocytes" @default.
- W1989355943 doi "https://doi.org/10.1159/000234099" @default.
- W1989355943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3488966" @default.
- W1989355943 hasPublicationYear "1986" @default.
- W1989355943 type Work @default.
- W1989355943 sameAs 1989355943 @default.
- W1989355943 citedByCount "15" @default.
- W1989355943 crossrefType "journal-article" @default.
- W1989355943 hasAuthorship W1989355943A5004078001 @default.
- W1989355943 hasAuthorship W1989355943A5059120671 @default.
- W1989355943 hasAuthorship W1989355943A5064301200 @default.
- W1989355943 hasConcept C126322002 @default.
- W1989355943 hasConcept C134018914 @default.
- W1989355943 hasConcept C19869320 @default.
- W1989355943 hasConcept C202751555 @default.
- W1989355943 hasConcept C203014093 @default.
- W1989355943 hasConcept C24998067 @default.
- W1989355943 hasConcept C2777371288 @default.
- W1989355943 hasConcept C2777761686 @default.
- W1989355943 hasConcept C2778690821 @default.
- W1989355943 hasConcept C2780372218 @default.
- W1989355943 hasConcept C2781005381 @default.
- W1989355943 hasConcept C2908885563 @default.
- W1989355943 hasConcept C55493867 @default.
- W1989355943 hasConcept C71924100 @default.
- W1989355943 hasConcept C86803240 @default.
- W1989355943 hasConceptScore W1989355943C126322002 @default.
- W1989355943 hasConceptScore W1989355943C134018914 @default.
- W1989355943 hasConceptScore W1989355943C19869320 @default.
- W1989355943 hasConceptScore W1989355943C202751555 @default.
- W1989355943 hasConceptScore W1989355943C203014093 @default.
- W1989355943 hasConceptScore W1989355943C24998067 @default.
- W1989355943 hasConceptScore W1989355943C2777371288 @default.
- W1989355943 hasConceptScore W1989355943C2777761686 @default.
- W1989355943 hasConceptScore W1989355943C2778690821 @default.
- W1989355943 hasConceptScore W1989355943C2780372218 @default.
- W1989355943 hasConceptScore W1989355943C2781005381 @default.
- W1989355943 hasConceptScore W1989355943C2908885563 @default.
- W1989355943 hasConceptScore W1989355943C55493867 @default.
- W1989355943 hasConceptScore W1989355943C71924100 @default.
- W1989355943 hasConceptScore W1989355943C86803240 @default.
- W1989355943 hasIssue "1" @default.
- W1989355943 hasLocation W19893559431 @default.
- W1989355943 hasLocation W19893559432 @default.
- W1989355943 hasOpenAccess W1989355943 @default.
- W1989355943 hasPrimaryLocation W19893559431 @default.
- W1989355943 hasRelatedWork W1989355943 @default.
- W1989355943 hasRelatedWork W1997681068 @default.
- W1989355943 hasRelatedWork W2042770929 @default.
- W1989355943 hasRelatedWork W2054992011 @default.
- W1989355943 hasRelatedWork W2064416809 @default.
- W1989355943 hasRelatedWork W2069573266 @default.
- W1989355943 hasRelatedWork W2081717119 @default.
- W1989355943 hasRelatedWork W2092831715 @default.
- W1989355943 hasRelatedWork W2407815207 @default.
- W1989355943 hasRelatedWork W2470957777 @default.
- W1989355943 hasVolume "81" @default.
- W1989355943 isParatext "false" @default.
- W1989355943 isRetracted "false" @default.
- W1989355943 magId "1989355943" @default.
- W1989355943 workType "article" @default.