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• W1989372014 abstract "To discriminate whether fatty acids are uncouplers that cause acceleration of State-4 respiration, associated with a decrease in the protonmotive force, or decouplers that increase respiration without associated decrease in the protonmotive force, we examined the effect of palmitate on functions of rat-liver mitochondria under various conditions. We found that palmitate itself increases State-4 respiration, releases oligomycin-inhibited State-3 respiration, inhibits ATP synthesis and ATP<->Pi exchange reaction, and increases H+ permeability in mitochondrial and model bilayer phospholipid membranes. Thus, palmitate is a classical uncoupler of oxidative phosphorylation. However, these effects were inhibited by Mg2+, due to rapid formation of a stable complex between palmitate and Mg2+." @default.
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• W1989372014 date "1995-03-01" @default.
• W1989372014 modified "2023-09-26" @default.
• W1989372014 title "Inhibitory effect of Mg2+ on the protonophoric activity of palmitic acid" @default.
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• W1989372014 doi "https://doi.org/10.1016/0005-2728(94)00179-9" @default.
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