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- W1989378081 endingPage "132" @default.
- W1989378081 startingPage "109" @default.
- W1989378081 abstract "Endogenous circadian rhythms govern most aspects of physiology and behaviour in mammals, including body temperature, autonomic and endocrine function, and sleep-wake cycles. Such rhythms are generated by the suprachiasmatic nucleus of the hypothalamus (SCN), but are synchronised to the environmental light-dark cycle by photic cues perceived by the retina and conveyed to the SCN via the retinohypothalamic tract (RHT). This review considers many lines of evidence from diverse experimental approaches indicating that the RHT employs glutamate (or a related excitatory amino acid) as a neurotransmitter. Ultrastructural studies demonstrate the presence of glutamate in presynaptic terminals within the SCN. In situ hybridisation and immunocytochemical studies reveal the presence of several NMDA (NMDAR1, NMDAR2C), non-NMDA (G1uR1, GluR2, GluR4) and metabotropic (mGluRl) glutamate receptor subunits in the SCN. Messenger RNA encoding a glutamate transporter protein is also present. In behavioural tests, glutamate antagonists can block the effects of light in phase-shifting circadian rhythms. Such treatments also block the induction of c-fos within SCN cells by light, whereas a glutamate agonist (NMDA) induces c-fos expression. In hypothalamic slice preparations in vitro, electrical stimulation of the optic nerves induces release of glutamate and aspartate, and glutamate antagonists block field potentials in the SCN evoked by stimulation of the optic nerve. Circadian rhythms of electrical activity which persist in vitro are phase shifted by application of glutamate in a manner which mimics the phase shifting effects of light in vivo. This wide range of experimental findings provides strong support for the hypothesis that glutamate is the principal neurotransmitter within the RHT, and thus conveys photic cues to the circadian timing system in the SCN." @default.
- W1989378081 created "2016-06-24" @default.
- W1989378081 creator A5060226730 @default.
- W1989378081 date "1996-10-01" @default.
- W1989378081 modified "2023-10-16" @default.
- W1989378081 title "The role of glutamate in the photic regulation of the suprachiasmatic nucleus" @default.
- W1989378081 cites W1003432337 @default.
- W1989378081 cites W1536211056 @default.
- W1989378081 cites W1541190820 @default.
- W1989378081 cites W1549812476 @default.
- W1989378081 cites W1560799253 @default.
- W1989378081 cites W1567544633 @default.
- W1989378081 cites W1594111906 @default.
- W1989378081 cites W1633420520 @default.
- W1989378081 cites W1643642661 @default.
- W1989378081 cites W181260436 @default.
- W1989378081 cites W1862839122 @default.
- W1989378081 cites W1863375292 @default.
- W1989378081 cites W1919210158 @default.
- W1989378081 cites W1967069646 @default.
- W1989378081 cites W1967796224 @default.
- W1989378081 cites W1969400861 @default.
- W1989378081 cites W1970130379 @default.
- W1989378081 cites W1971655439 @default.
- W1989378081 cites W1972183007 @default.
- W1989378081 cites W1972437651 @default.
- W1989378081 cites W1972546360 @default.
- W1989378081 cites W1973640817 @default.
- W1989378081 cites W1975522748 @default.
- W1989378081 cites W1976373254 @default.
- W1989378081 cites W1976562502 @default.
- W1989378081 cites W1976644978 @default.
- W1989378081 cites W1978531717 @default.
- W1989378081 cites W1980228648 @default.
- W1989378081 cites W1981458961 @default.
- W1989378081 cites W1982545791 @default.
- W1989378081 cites W1982845245 @default.
- W1989378081 cites W1983662955 @default.
- W1989378081 cites W1983935664 @default.
- W1989378081 cites W1984374781 @default.
- W1989378081 cites W1985816593 @default.
- W1989378081 cites W1986240433 @default.
- W1989378081 cites W1986413865 @default.
- W1989378081 cites W1986445622 @default.
- W1989378081 cites W1989670552 @default.
- W1989378081 cites W1990723143 @default.
- W1989378081 cites W1992182952 @default.
- W1989378081 cites W1992414754 @default.
- W1989378081 cites W1992756422 @default.
- W1989378081 cites W1993597470 @default.
- W1989378081 cites W1996805443 @default.
- W1989378081 cites W1997682456 @default.
- W1989378081 cites W1998448534 @default.
- W1989378081 cites W1999160850 @default.
- W1989378081 cites W1999384796 @default.
- W1989378081 cites W1999446521 @default.
- W1989378081 cites W1999744000 @default.
- W1989378081 cites W1999969694 @default.
- W1989378081 cites W2001187994 @default.
- W1989378081 cites W2001711337 @default.
- W1989378081 cites W2003179182 @default.
- W1989378081 cites W2005862779 @default.
- W1989378081 cites W2006068389 @default.
- W1989378081 cites W2007142524 @default.
- W1989378081 cites W2007571881 @default.
- W1989378081 cites W2008697458 @default.
- W1989378081 cites W2011223835 @default.
- W1989378081 cites W2011400731 @default.
- W1989378081 cites W2012317070 @default.
- W1989378081 cites W2012380187 @default.
- W1989378081 cites W2012391414 @default.
- W1989378081 cites W2014015174 @default.
- W1989378081 cites W2016532659 @default.
- W1989378081 cites W2016555592 @default.
- W1989378081 cites W2016720840 @default.
- W1989378081 cites W2017171491 @default.
- W1989378081 cites W2017329375 @default.
- W1989378081 cites W2018823590 @default.
- W1989378081 cites W2018996301 @default.
- W1989378081 cites W2019297438 @default.
- W1989378081 cites W2019348964 @default.
- W1989378081 cites W2019358608 @default.
- W1989378081 cites W2019491755 @default.
- W1989378081 cites W2020364712 @default.
- W1989378081 cites W2021550464 @default.
- W1989378081 cites W2022107364 @default.
- W1989378081 cites W2022123095 @default.
- W1989378081 cites W2024228896 @default.
- W1989378081 cites W2024808011 @default.
- W1989378081 cites W2024945446 @default.
- W1989378081 cites W2025558453 @default.
- W1989378081 cites W2025661173 @default.
- W1989378081 cites W2028394964 @default.
- W1989378081 cites W2031183077 @default.
- W1989378081 cites W2032008843 @default.
- W1989378081 cites W2032860821 @default.
- W1989378081 cites W2034068120 @default.
- W1989378081 cites W2034648222 @default.