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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989403033> ?p ?o ?g. }

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• W1989403033 abstract "Hypersensitivity reactions to drugs can cause a variety of different skin disorders, the most frequent being maculopapular eruptions. In recent years increasing evidence has indicated the important involvement of T cells in this drug reaction. Histopathological changes typically show a dominant T-cell infiltration together with vacuolar interface dermatitis. Immunohistochemical studies demonstrate the presence of cytotoxic CD4+ and CD8+ T cells, which contain perforin and granzyme B, in close proximity to keratinocytes showing signs of cell destruction. Expression of Fas ligand is barely detectable, which suggests that cytotoxic granule exocytosis may be the dominant pathway leading to keratinocyte cell damage. In addition, drug-specific T cells may orchestrate the inflammatory skin reaction through the release and induction of various cytokines (i.e. IL-5, IL-6, TNF-alpha, IFN-gamma) and chemokines (i.e. regulated on activation, normal T-cell expressed and secreted; eotaxin). These mediators contribute to the generation of eosinophilia, which may amplify the underlying immune response through the release of further proinflammatory mediators in drug-induced maculopapular exanthema." @default.
• W1989403033 created "2016-06-24" @default.
• W1989403033 creator A5073211217 @default.
• W1989403033 creator A5076464910 @default.
• W1989403033 date "2001-08-01" @default.
• W1989403033 modified "2023-09-26" @default.
• W1989403033 title "Immunohistology of drug-induced exanthema: clues to pathogenesis" @default.
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• W1989403033 doi "https://doi.org/10.1097/01.all.0000011030.52248.1b" @default.
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