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- W1989412047 abstract "Mechanical stimulation of osteoblasts has been shown to induce changes in phenotype at the cellular level. The cellular changes resulting from the mechanical stretching of human osteoblast-like cells (MG-63) cultured on flexible silicone-coated films were investigated. With a quantitative competitive polymerase chain reaction (PCR) methods, whether mechanical stimuli induce osteogenic gene expressions and cytokine productions in the mechanical stretching of human osteoblast-like cells (MG-63) cells was examined. Expressions of protooncogene (c-fos), bone morphogenic proteins (BMP-2 and BMP-4), and the BMPs’ receptor, i.e. activin receptor-like kinase-3 (ALK-3), increased after stretching. c-fos, BMP-2, and BMP-4 mRNA levels reached their peaks 0.5 h after stretching began, while ALK-3 mRNA reached a maximum level 2 h after stretching started. When the culture medium was assayed for cytokine activities, macrophage-colony stimulating factor (M-CSF) was found at the maximum concentration after 4 h of stretching. These results suggest that mechanical stimuli affect the expressions of BMPs and their receptors, and the continuous M-CSF expression might induce differentiation of osteoblasts." @default.
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- W1989412047 date "1999-04-01" @default.
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- W1989412047 title "Mechanical stretching of human osteoblast-like cells stimulates bone morphogenic proteins and macrophage colony-stimulating factor productions" @default.
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- W1989412047 doi "https://doi.org/10.1016/s0928-4680(99)00003-6" @default.
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