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• W1989418829 endingPage "H2278" @default.
• W1989418829 startingPage "H2271" @default.
• W1989418829 abstract "The adventitia has been recognized to play important roles in vascular oxidative stress, remodeling, and contraction. We recently demonstrated that adventitial fibroblasts are able to express endothelin (ET)-1 in response to ANG II. However, it is unclear whether ET-1 receptors are expressed in the adventitia. We therefore investigated the expression and roles of both ET A and ET B receptors in collagen synthesis and ET-1 clearance in adventitial fibroblasts. Adventitial fibroblasts were isolated and cultured from the mouse thoracic aorta by the explant method. Cultured cells were treated with ANG II (100 nmol/l) or ET-1 (10 pM) in the presence or absence of the ANG II type 1 receptor antagonist losartan (100 μM), the ET-1 receptor antagonists BQ-123 (ET A receptor, 1 μM) and BQ-788 (ET B receptor, 1 μM), and the ET B receptor agonist sarafotoxin 6C (100 nM). ET-1 peptide levels were determined by ELISA, whereas ET A , ET B , and collagen levels were determined by Western blot analysis. ANG II increased ET-1 peptide levels in a time-dependent manner. ANG II increased ET A and ET B receptor protein levels as well as collagen in a similar fashion. ANG II-induced collagen was reduced while in the presence of BQ-123, suggesting a role for the ET A receptor in the regulation of the extracellular matrix. ANG II treatment in the presence of BQ-788 significantly increased ET-1 peptide levels. Conversely, the ET B receptor agonist sarafotoxin 6C significantly decreased ET-1 peptide levels. These data implicate a role for the ET B receptor in the clearance of the ET-1 peptide. In conclusion, both ET A and ET B receptors are expressed in adventitial fibroblasts, which paves the ground for the biological significance of adventitial ET-1. The ET A receptor subtype mediates collagen I expression, whereas the ET B receptor subtype may play a protective role through increasing the clearance of the ET-1 peptide." @default.
• W1989418829 created "2016-06-24" @default.
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• W1989418829 date "2011-12-01" @default.
• W1989418829 modified "2023-10-18" @default.
• W1989418829 title "ET_A and ET_B receptors are expressed in vascular adventitial fibroblasts" @default.
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• W1989418829 doi "https://doi.org/10.1152/ajpheart.00869.2010" @default.
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