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- W1989437954 abstract "The individual stereoisomers of mianserin were tested in pithed normotensive rats for their antagonistic activity at vascular postjunctional α1- and α2-adrenoceptors as well as their interaction with the ‘amine pump receptor’. (+)-Mianserin was found approximately five time more potent than (−)-mianserin in antagonizing the increase in diastolic pressure brought about by either selective α1 (agonist: methoxamine)- or α2 (agonist: B-HT 920)-adrenoceptor stimulation. (+)-Mianserin also behaved as the more effective displacer of [3H]prazosin and [3H]clonidine binding to rat brain membranes. Tyramine, an indirectly acting sympathomimetic agent, increased the resting heart rate of pithed rats. This effect was competitively antagonised by the noradrenaline uptakeinhibitor desipramine. (−)-Mianserin was inactive in inhibiting the tyramine-induced increase in heart rate. (+)-Mianserin showed some activity, but was much less potent than desipramine. The present results clearly indicate that (+)-mianserin is the pharmacologically more active isomer." @default.
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- W1989437954 date "1983-06-01" @default.
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- W1989437954 title "Effects of (+)- and (−)-Mianserin on α-adrenoceptors and tyramine-induced tachycardia in rats" @default.
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- W1989437954 doi "https://doi.org/10.1016/0014-2999(83)90240-6" @default.
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