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• W1989469651 abstract "RT4 is a family of cell lines derived from a rat peripheral neurotumor and consists of a multipotential stem cell which spontaneously gives rise to a glial derivative and two neuronal derivatives. To begin to understand the role(s) of transcription factors in neural differentiation, we examined the expression of ten transcription factor genes (MASH1, REST/NRSF, Oct-1, Oct-2, Tst-1/SCIP, Brn-1, Brn-2, Brn-3.0, Brn-4, Brn-5) in the RT4 cell lines. We report here that all of the RT4 cells express REST/NRSF, Oct-1 and Brn-5, but do not express MASH1, Brn-3.0 or Brn-4. Furthermore, Brn-2 and Tst-1/SCIP expression was restricted to the RT4 stem cell line and glial derivative, while Oct-2 was expressed predominantly by the RT4 stem cell line and neuronal derivatives. We propose that the lack of expression of MASH1 (which is expressed relatively early in autonomic neuron differentiation) and Brn-3.0 (which is expressed early in sensory neuron differentiation), in combination with the presence of REST/NRSF (a repressor of neuronal gene expression), in all of the RT4 cell lines, establishes the RT4 system as a unique model for examining very early events in neuronal versus glial cell fate determination." @default.
• W1989469651 created "2016-06-24" @default.
• W1989469651 creator A5046193124 @default.
• W1989469651 creator A5084232708 @default.
• W1989469651 date "1998-03-01" @default.
• W1989469651 modified "2023-09-27" @default.
• W1989469651 title "POU domain genes are differentially expressed in the early stages after lineage commitment of the PNS-derived stem cell line, RT4-AC" @default.
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• W1989469651 doi "https://doi.org/10.1016/s0165-3806(97)00154-5" @default.
• W1989469651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9554933" @default.
• W1989469651 hasPublicationYear "1998" @default.
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