FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989469887> ?p ?o ?g. }

• W1989469887 endingPage "48" @default.
• W1989469887 startingPage "27" @default.
• W1989469887 abstract "Ethylene oxide (EO) is mutagenic in various in vitro and in vivo test systems and carcinogenic in rodents. EO forms different adducts upon reaction with DNA, N7-(2-hydroxyethyl)guanine (N7-HEG) being the main adduct. The major objectives of this study were: (a) to determine the formation and persistence of N7-HEG adducts in liver DNA of adult male rats exposed to 0, 50, 100 and 200 ppm by inhalation (4 weeks, 5 days/week, 6 h/day) and (b) to assess dose-response relationships for Hprt gene mutations and various types of chromosomal changes in splenic lymphocytes.N7-HEG adducts were measured 5, 21, 35 and 49 days after cessation of exposure. By extrapolation, the mean concentrations of N7-HEG immediately after cessation of exposure ('day 0') to 50, 100 and 200 ppm were calculated as 310, 558 and 1202 adducts/10(8) nucleotides, respectively, while the mean concentration in control rats was 2.6 adducts/10(8) nucleotides. At 49 days, N7-HEG values had returned close to background levels. The mean levels of N-(2-hydroxyethylvaline) adducts in haemoglobin were also determined and amounted 61.7, 114 and 247 nmol/g globin, respectively. Statistically significant linear relationships were found between mean N7-HEG levels ('day 0') and Hprt mutant frequencies at expression times 21/22 and 49/50 days and between mean N7-HEG ('day 0') and sister-chromatid exchanges (SCEs) or high frequency cells (HFC) measured 5 days post-exposure. At day 21 post-exposure, SCEs and HFCs in-part persisted and were significantly correlated with persistent N7-HEG adducts. No statistically significant dose effect relationships were observed for induction of micronuclei, nor for chromosome breaks or translocations. In conclusion, this study indicates that following sub-chronic exposure, EO is only weakly mutagenic in adult rats. Using the data of this study to predict cancer risk in man resulting from low level EO exposures in conjunction with other published data, i.e., those on (a) genotoxic effects of EO in humans and rats, (b) DNA binding of other carcinogens, (c) natural background DNA binding and (d) genotoxic potency of low energy transfer (LET) radiation, it is not expected that long term occupational exposure to airborne concentrations of EO at or below 1 ppm EO produces an unacceptable increased risk in man." @default.
• W1989469887 created "2016-06-24" @default.
• W1989469887 creator A5011735913 @default.
• W1989469887 creator A5016045810 @default.
• W1989469887 creator A5025807181 @default.
• W1989469887 creator A5028765820 @default.
• W1989469887 creator A5038245959 @default.
• W1989469887 creator A5044300222 @default.
• W1989469887 date "2000-01-01" @default.
• W1989469887 modified "2023-10-08" @default.
• W1989469887 title "Formation of DNA adducts and induction of mutagenic effects in rats following 4 weeks inhalation exposure to ethylene oxide as a basis for cancer risk assessment" @default.
• W1989469887 cites W119636600 @default.
• W1989469887 cites W15858186 @default.
• W1989469887 cites W1963634283 @default.
• W1989469887 cites W1963682115 @default.
• W1989469887 cites W1965169790 @default.
• W1989469887 cites W1974614914 @default.
• W1989469887 cites W1975102042 @default.
• W1989469887 cites W1978970842 @default.
• W1989469887 cites W1982256719 @default.
• W1989469887 cites W1985992088 @default.
• W1989469887 cites W1986359722 @default.
• W1989469887 cites W1992388160 @default.
• W1989469887 cites W1996041476 @default.
• W1989469887 cites W2002976054 @default.
• W1989469887 cites W2002994696 @default.
• W1989469887 cites W2014977920 @default.
• W1989469887 cites W2018381257 @default.
• W1989469887 cites W2018841144 @default.
• W1989469887 cites W2019040943 @default.
• W1989469887 cites W2019361234 @default.
• W1989469887 cites W2023927250 @default.
• W1989469887 cites W2025331873 @default.
• W1989469887 cites W2029847744 @default.
• W1989469887 cites W2031863702 @default.
• W1989469887 cites W2038808046 @default.
• W1989469887 cites W2042057331 @default.
• W1989469887 cites W2045170184 @default.
• W1989469887 cites W2045651871 @default.
• W1989469887 cites W2047633314 @default.
• W1989469887 cites W2048626332 @default.
• W1989469887 cites W2050350173 @default.
• W1989469887 cites W2051875045 @default.
• W1989469887 cites W2051883309 @default.
• W1989469887 cites W2052748587 @default.
• W1989469887 cites W2055399665 @default.
• W1989469887 cites W2066182848 @default.
• W1989469887 cites W2066273171 @default.
• W1989469887 cites W2068747346 @default.
• W1989469887 cites W2074918018 @default.
• W1989469887 cites W2078382033 @default.
• W1989469887 cites W2083047280 @default.
• W1989469887 cites W2088724807 @default.
• W1989469887 cites W2094855011 @default.
• W1989469887 cites W2105015778 @default.
• W1989469887 cites W2132168302 @default.
• W1989469887 cites W2141712765 @default.
• W1989469887 cites W2145099685 @default.
• W1989469887 cites W2149213081 @default.
• W1989469887 cites W2314667127 @default.
• W1989469887 cites W4234575844 @default.
• W1989469887 cites W4235290795 @default.
• W1989469887 doi "https://doi.org/10.1016/s0027-5107(99)00208-0" @default.
• W1989469887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10686305" @default.
• W1989469887 hasPublicationYear "2000" @default.
• W1989469887 type Work @default.
• W1989469887 sameAs 1989469887 @default.
• W1989469887 citedByCount "47" @default.
• W1989469887 countsByYear W19894698872012 @default.
• W1989469887 countsByYear W19894698872013 @default.
• W1989469887 countsByYear W19894698872014 @default.
• W1989469887 countsByYear W19894698872017 @default.
• W1989469887 countsByYear W19894698872018 @default.
• W1989469887 countsByYear W19894698872019 @default.
• W1989469887 countsByYear W19894698872020 @default.
• W1989469887 countsByYear W19894698872022 @default.
• W1989469887 countsByYear W19894698872023 @default.
• W1989469887 crossrefType "journal-article" @default.
• W1989469887 hasAuthorship W1989469887A5011735913 @default.
• W1989469887 hasAuthorship W1989469887A5016045810 @default.
• W1989469887 hasAuthorship W1989469887A5025807181 @default.
• W1989469887 hasAuthorship W1989469887A5028765820 @default.
• W1989469887 hasAuthorship W1989469887A5038245959 @default.
• W1989469887 hasAuthorship W1989469887A5044300222 @default.
• W1989469887 hasConcept C104317684 @default.
• W1989469887 hasConcept C108204754 @default.
• W1989469887 hasConcept C114246631 @default.
• W1989469887 hasConcept C153911025 @default.
• W1989469887 hasConcept C15920480 @default.
• W1989469887 hasConcept C178790620 @default.
• W1989469887 hasConcept C185592680 @default.
• W1989469887 hasConcept C207001950 @default.
• W1989469887 hasConcept C2776954882 @default.
• W1989469887 hasConcept C2777801237 @default.
• W1989469887 hasConcept C2778301229 @default.
• W1989469887 hasConcept C2781247443 @default.
• W1989469887 hasConcept C30481170 @default.
• W1989469887 hasConcept C42219234 @default.

• next