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- W1989470448 endingPage "157" @default.
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- W1989470448 abstract "Estrogens fluctuate across the lifespan in women, with circulating 17β-estradiol levels higher pre-menopause than estrone and circulating estrone levels higher postmenopause than 17β-estradiol. Estrone is a common component of hormone replacement therapies, but research shows that 17β-estradiol may have a greater positive impact on cognition. Previous studies show that acute estrone and 17β-estradiol impact hippocampus-dependent learning and cell proliferation in the dentate gyrus in a dose-dependent manner in adult female rats. The current study explores how chronic treatment with estrone and 17β-estradiol differentially influences spatial learning, hippocampal neurogenesis and activation of new neurons in response to spatial memory. Adult female rats received daily injections of vehicle (sesame oil), or a 10 μg dose of either 17β-estradiol or estrone for 20 days. One day following the first hormone injection all rats were injected with the DNA synthesis marker, bromodeoxyuridine. On days 11–15 after BrdU injection rats were trained on a spatial reference version of the Morris water maze, and five days later (day 20 of estrogens treatment) were given a probe trial to assess memory retention. Cell proliferation was assessed by the endogenous cell cycle marker, Ki67, cell survival was assessed by counting the number and density of BrdU-ir cells in the dentate gyrus and cell activation was assessed by the percentage of BrdU-ir cells that were co-labelled with the immediate early gene product zif268. There were no significant differences between groups in acquisition or retention of Morris water maze. However, the 17β-estradiol group had significantly higher, while the estrone group had significantly lower, levels of cell survival (BrdU-ir cells) in the dentate gyrus compared to controls. Furthermore, rats injected with 17β-estradiol showed significantly higher levels of activation of new neurons in response to spatial memory compared to controls. These results provide insight into how estrogens differentially influence the brain and behavior, and may provide insight into the development of hormone replacement therapies for women." @default.
- W1989470448 created "2016-06-24" @default.
- W1989470448 creator A5050802124 @default.
- W1989470448 creator A5063120236 @default.
- W1989470448 creator A5077638545 @default.
- W1989470448 date "2013-01-01" @default.
- W1989470448 modified "2023-10-18" @default.
- W1989470448 title "17β-Estradiol, but not estrone, increases the survival and activation of new neurons in the hippocampus in response to spatial memory in adult female rats" @default.
- W1989470448 cites W151073356 @default.
- W1989470448 cites W1581458838 @default.
- W1989470448 cites W1739953941 @default.
- W1989470448 cites W1833278024 @default.
- W1989470448 cites W1948207118 @default.
- W1989470448 cites W1963969109 @default.
- W1989470448 cites W1971561877 @default.
- W1989470448 cites W1972928390 @default.
- W1989470448 cites W1973369788 @default.
- W1989470448 cites W1973825987 @default.
- W1989470448 cites W1978244700 @default.
- W1989470448 cites W1978488532 @default.
- W1989470448 cites W1978543883 @default.
- W1989470448 cites W1978937181 @default.
- W1989470448 cites W1982541490 @default.
- W1989470448 cites W1986204185 @default.
- W1989470448 cites W1986662149 @default.
- W1989470448 cites W1987375164 @default.
- W1989470448 cites W1990765405 @default.
- W1989470448 cites W1991712257 @default.
- W1989470448 cites W1993176591 @default.
- W1989470448 cites W1993796132 @default.
- W1989470448 cites W1996396637 @default.
- W1989470448 cites W1997996573 @default.
- W1989470448 cites W2002090514 @default.
- W1989470448 cites W2002366505 @default.
- W1989470448 cites W2002759659 @default.
- W1989470448 cites W2006594778 @default.
- W1989470448 cites W2010395737 @default.
- W1989470448 cites W2011153961 @default.
- W1989470448 cites W2012438895 @default.
- W1989470448 cites W2012776040 @default.
- W1989470448 cites W2014570372 @default.
- W1989470448 cites W2018384424 @default.
- W1989470448 cites W2021229480 @default.
- W1989470448 cites W2025604203 @default.
- W1989470448 cites W2029334700 @default.
- W1989470448 cites W2032133490 @default.
- W1989470448 cites W2032679733 @default.
- W1989470448 cites W2034093030 @default.
- W1989470448 cites W2034627732 @default.
- W1989470448 cites W2042033702 @default.
- W1989470448 cites W2042199152 @default.
- W1989470448 cites W2043734033 @default.
- W1989470448 cites W2044103334 @default.
- W1989470448 cites W2046448671 @default.
- W1989470448 cites W2046708720 @default.
- W1989470448 cites W2053047725 @default.
- W1989470448 cites W2054091180 @default.
- W1989470448 cites W2059601159 @default.
- W1989470448 cites W2060488963 @default.
- W1989470448 cites W2060889804 @default.
- W1989470448 cites W2065126520 @default.
- W1989470448 cites W2067856703 @default.
- W1989470448 cites W2068715691 @default.
- W1989470448 cites W2069849707 @default.
- W1989470448 cites W2071973307 @default.
- W1989470448 cites W2073353512 @default.
- W1989470448 cites W2073436852 @default.
- W1989470448 cites W2073883348 @default.
- W1989470448 cites W2076239324 @default.
- W1989470448 cites W2078045367 @default.
- W1989470448 cites W2080979269 @default.
- W1989470448 cites W2082861309 @default.
- W1989470448 cites W2083868147 @default.
- W1989470448 cites W2083975235 @default.
- W1989470448 cites W2084072562 @default.
- W1989470448 cites W2089964981 @default.
- W1989470448 cites W2090518321 @default.
- W1989470448 cites W2091345176 @default.
- W1989470448 cites W2091474780 @default.
- W1989470448 cites W2092049238 @default.
- W1989470448 cites W2092919706 @default.
- W1989470448 cites W2097408153 @default.
- W1989470448 cites W2104231345 @default.
- W1989470448 cites W2111727127 @default.
- W1989470448 cites W2111869840 @default.
- W1989470448 cites W2118112130 @default.
- W1989470448 cites W2120889805 @default.
- W1989470448 cites W2123652060 @default.
- W1989470448 cites W2123927100 @default.
- W1989470448 cites W2131266318 @default.
- W1989470448 cites W2133381675 @default.
- W1989470448 cites W2133565799 @default.
- W1989470448 cites W2133910658 @default.
- W1989470448 cites W2135910109 @default.
- W1989470448 cites W2136076162 @default.
- W1989470448 cites W2136249808 @default.
- W1989470448 cites W2141188066 @default.
- W1989470448 cites W2145884075 @default.