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- W1989475487 abstract "Antiadrenergic treatment is currently an emerging and very promising approach to the treatment of chronic heart failure. Although the adrenergic nervous system can be pharmacologically inhibited at multiple levels, it is the use of receptor-blocking agents that has generated the most interest and provided the most data for the proof of concept of this approach. In part because antiadrenergic treatment of chronic heart failure has developed in an atmosphere in which it was initially considered to be contraindicated (i.e., before Phase III clinical trials could be initiated), a large body of hypothesis-driven basic and clinical investigation was required to define the overall rationale and demonstrate feasibility. This article will review these data and propose a single primary mechanism of action to explain most of the clinical benefits of these agents." @default.
- W1989475487 created "2016-06-24" @default.
- W1989475487 creator A5042834490 @default.
- W1989475487 date "1997-12-01" @default.
- W1989475487 modified "2023-10-14" @default.
- W1989475487 title "Mechanism of Action of Beta-Blocking Agents in Heart Failure" @default.
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