FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989493313> ?p ?o ?g. }

• W1989493313 endingPage "384" @default.
• W1989493313 startingPage "379" @default.
• W1989493313 abstract "Several human diseases are associated with the <I>NUAK1</I> and <I>NUAK2</I> genes. These genes encode kinases, members of the AMPK-related kinases (ARK) gene family. Both NUAK1 and NUAK2 are known targets of the serine threonine kinase LKB1, a tumor suppressor involved in regulating cell polarity. While much is known about their functions in disease, their expression pattern in normal development has not been extensively studied. Here, we present the expression patterns for <I>NUAK1</I> and <I>NUAK2</I> in the chick during early-stage embryogenesis, until day 3 (Hamburger and Hamilton stage HH20). Several embryonic structures, in particular the nascent head, showed distinct expression levels. <I>NUAK1</I> expression was first detected at stage HH6 in the rostral neural folds. It was then expressed (HH7-11) throughout the encephalalon, predominantly in the telencephalon and mesencephalon. <I>NUAK1 </I>expression was also detected in the splanchnic endoderm area at HH8-10, and in the vitellin vein derived from this area, but not in the heart. <I>NUAK2</I> expression was first detected at stage HH6 in the neural folds. It was then found throughout the encephalon at stage HH20. Particular attention was paid in this study to the dorsal ectoderm at stages HH7 and HH8, where a local deficit or accumulation of <I>NUAK2</I> mRNA were found to correlate with the direction of curvature of the neural plate. This is the first description of <I>NUAK1</I> and <I>NUAK2 </I>expression patterns in the chick during early development; it reveals non-identical expression profiles for both genes in neural development." @default.
• W1989493313 created "2016-06-24" @default.
• W1989493313 creator A5047214465 @default.
• W1989493313 creator A5055989986 @default.
• W1989493313 creator A5080362393 @default.
• W1989493313 date "2014-01-01" @default.
• W1989493313 modified "2023-10-14" @default.
• W1989493313 title "Analysis of NUAK1 and NUAK2 expression during early chick development reveals specific patterns in the developing head" @default.
• W1989493313 doi "https://doi.org/10.1387/ijdb.140024jt" @default.
• W1989493313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25354459" @default.
• W1989493313 hasPublicationYear "2014" @default.
• W1989493313 type Work @default.
• W1989493313 sameAs 1989493313 @default.
• W1989493313 citedByCount "7" @default.
• W1989493313 countsByYear W19894933132016 @default.
• W1989493313 countsByYear W19894933132017 @default.
• W1989493313 countsByYear W19894933132018 @default.
• W1989493313 countsByYear W19894933132020 @default.
• W1989493313 countsByYear W19894933132022 @default.
• W1989493313 crossrefType "journal-article" @default.
• W1989493313 hasAuthorship W1989493313A5047214465 @default.
• W1989493313 hasAuthorship W1989493313A5055989986 @default.
• W1989493313 hasAuthorship W1989493313A5080362393 @default.
• W1989493313 hasBestOaLocation W19894933131 @default.
• W1989493313 hasConcept C104317684 @default.
• W1989493313 hasConcept C145103041 @default.
• W1989493313 hasConcept C196843134 @default.
• W1989493313 hasConcept C2777164004 @default.
• W1989493313 hasConcept C2779329299 @default.
• W1989493313 hasConcept C2780915607 @default.
• W1989493313 hasConcept C54355233 @default.
• W1989493313 hasConcept C86803240 @default.
• W1989493313 hasConcept C87073359 @default.
• W1989493313 hasConcept C95444343 @default.
• W1989493313 hasConceptScore W1989493313C104317684 @default.
• W1989493313 hasConceptScore W1989493313C145103041 @default.
• W1989493313 hasConceptScore W1989493313C196843134 @default.
• W1989493313 hasConceptScore W1989493313C2777164004 @default.
• W1989493313 hasConceptScore W1989493313C2779329299 @default.
• W1989493313 hasConceptScore W1989493313C2780915607 @default.
• W1989493313 hasConceptScore W1989493313C54355233 @default.
• W1989493313 hasConceptScore W1989493313C86803240 @default.
• W1989493313 hasConceptScore W1989493313C87073359 @default.
• W1989493313 hasConceptScore W1989493313C95444343 @default.
• W1989493313 hasIssue "5" @default.
• W1989493313 hasLocation W19894933131 @default.
• W1989493313 hasLocation W19894933132 @default.
• W1989493313 hasOpenAccess W1989493313 @default.
• W1989493313 hasPrimaryLocation W19894933131 @default.
• W1989493313 hasRelatedWork W2017546359 @default.
• W1989493313 hasRelatedWork W2052598541 @default.
• W1989493313 hasRelatedWork W2053070851 @default.
• W1989493313 hasRelatedWork W2064236535 @default.
• W1989493313 hasRelatedWork W2095035432 @default.
• W1989493313 hasRelatedWork W2142205197 @default.
• W1989493313 hasRelatedWork W2158713637 @default.
• W1989493313 hasRelatedWork W2466474323 @default.
• W1989493313 hasRelatedWork W3147523926 @default.
• W1989493313 hasRelatedWork W4361271082 @default.
• W1989493313 hasVolume "58" @default.
• W1989493313 isParatext "false" @default.
• W1989493313 isRetracted "false" @default.
• W1989493313 magId "1989493313" @default.
• W1989493313 workType "article" @default.