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- W1989505575 abstract "however, RRSP may be substantially more common. Two recent reports from Oklahoma indicate that RRSP were recovered in 6 of 36 (16.7%) instances from children 6 and in 16 of 103 (15.5%) instances from a general population. 7 In our survey, approximately 3% of the pneumococcal isolates were relatively resistant to penicillin. More surveys from various geographic locations are obviously needed to assess the overall frequency of RRSP. The clinical significance of relative resistance to penicillin is important primarily in cases of pneumococcal meningitis. Penicillin levels in CSF are considerablY lower than simultaneous serum levels, particularly in the absence of meningeal inflammation. TM Peak penicillin concentrations in CSF of < 1.0/~g/ml are very commonly observed when standard penicillin doses are administered. '~ Therefore, pneumococcal meningitis caused by a RRSP may not be responsive to penicillin therapy. Indeed, all reported relapses or prolonged illnesses have been in patients with meningitis? ' ~' ~ Based on our experience and on some recent reports, we recommend that pneumococcal isolates from clinical specimens (and particularly CSF) should be screened for penicillin resistance using 1 /~g oxacillin discs. MIC determinations should be done on isolates yielding zones < 20 mm." @default.
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- W1989505575 date "1980-12-01" @default.
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- W1989505575 title "Significance of plasma β-thromboglobulin values in patients with sickle cell disease" @default.
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- W1989505575 doi "https://doi.org/10.1016/s0022-3476(80)80427-6" @default.
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