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- W1989515850 abstract "We have previously demonstrated that IFN-αβ poly I:C (an inducer of IFN-αβ), and IFN-γ can inhibit the ability of KLH-pulsed peritoneal macrophages to induce proliferation of syngeneic, KLH immune T lymphocytes in CBA/J mice. In this study, we show that this IFN-induced immunosuppression is not restricted to CBA/J (H-2k) mice but is also seen in BALB/cJ (H-2d) mice. A similar inhibition of proliferation is observed with the KLH-specific T cell hybridoma BDK. 100, which requires KLH-pulsed macrophages for optimum proliferation and IL-2 production. The immunosuppression produced by IFN was also independent of the antigen employed. Inhibition of T lymphocyte proliferation was observed when casein, instead of KLH, was used to immunize T cells and to pulse peritoneal macrophages in vivo. Utilizing KLH and casein, the antigen specificity of the inhibition was demonstrated. Therefore, the inhibition by the IFN-inducer poly I:C of macrophage-induced, antigen-specific T cell proliferation is not limited by H-2 type of the mice or to one antigen." @default.
- W1989515850 created "2016-06-24" @default.
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- W1989515850 date "1991-06-01" @default.
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- W1989515850 title "Inhibition of macrophage-induced antigen-specific T lymphocyte proliferation by poly I:C: Strain and antigen independence" @default.
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- W1989515850 doi "https://doi.org/10.1016/0008-8749(91)90250-f" @default.
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