FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989519898> ?p ?o ?g. }

• W1989519898 endingPage "216" @default.
• W1989519898 startingPage "209" @default.
• W1989519898 abstract "Adult T cell leukemia (ATL) is an aggressive malignancy that is associated with HTLV-I infection and characterized by constitutive expression of the high-affinity interleukin-2 receptor. The α subunit of the high-affinity receptor (IL-2Rα), which is normally present only on activated T cells, is specifically upregulated by HTLV-I and constitutively expressed on fresh leukemic cells from ATL patients as well as cell lines transformed by HTLV-Iin vitro.Here we directly address the functional significance of IL-2Rα expression in HTLV-I transformed cell lines by using an endoplasmic reticulum-targeted single-chain antibody to inhibit the cell surface expression of IL-2Rα. Using constitutive and tetracycline-repressible systems to express the ER-targeted antibody against IL-2Rα, we have reduced cell surface expression of IL-2Rα by more that 2 logs of mean fluorescence intensity to virtually undetectable levels in the IL-2-independent HTLV-I-transformed cell lines C8166-45 and HUT102. No toxicity was associated with the intracellular retention of IL-2Rα, and the growth rate of the IL-2Rα-negative cells was in each case comparable to that of the parental cell line. We conclude that cell surface expression of IL-2Rα is dispensable for thein vitrogrowth of these HTLV-I-transformed cells." @default.
• W1989519898 created "2016-06-24" @default.
• W1989519898 creator A5000780125 @default.
• W1989519898 creator A5035996420 @default.
• W1989519898 creator A5071476197 @default.
• W1989519898 creator A5085681127 @default.
• W1989519898 date "1997-10-01" @default.
• W1989519898 modified "2023-10-15" @default.
• W1989519898 title "Inducible Knockout of the Interleukin-2 Receptor α Chain: Expression of the High-Affinity IL-2 Receptor Is Not Required for thein VitroGrowth of HTLV-I-Transformed Cell Lines" @default.
• W1989519898 cites W108417128 @default.
• W1989519898 cites W1492660583 @default.
• W1989519898 cites W1564692190 @default.
• W1989519898 cites W1578073718 @default.
• W1989519898 cites W159302622 @default.
• W1989519898 cites W1606216715 @default.
• W1989519898 cites W1622349285 @default.
• W1989519898 cites W1675066089 @default.
• W1989519898 cites W179591200 @default.
• W1989519898 cites W1851382825 @default.
• W1989519898 cites W1986362127 @default.
• W1989519898 cites W2014464617 @default.
• W1989519898 cites W2017190280 @default.
• W1989519898 cites W2025226292 @default.
• W1989519898 cites W2028519890 @default.
• W1989519898 cites W2029312116 @default.
• W1989519898 cites W2056067293 @default.
• W1989519898 cites W2058350611 @default.
• W1989519898 cites W2068211039 @default.
• W1989519898 cites W2079011320 @default.
• W1989519898 cites W2079135245 @default.
• W1989519898 cites W2080431132 @default.
• W1989519898 cites W2088162695 @default.
• W1989519898 cites W2088621363 @default.
• W1989519898 cites W2090429649 @default.
• W1989519898 cites W2097765112 @default.
• W1989519898 cites W2100815929 @default.
• W1989519898 cites W2107198302 @default.
• W1989519898 cites W2107310088 @default.
• W1989519898 cites W2120274247 @default.
• W1989519898 cites W2127048642 @default.
• W1989519898 cites W2132958485 @default.
• W1989519898 cites W2133811759 @default.
• W1989519898 cites W2137847377 @default.
• W1989519898 cites W2155826396 @default.
• W1989519898 cites W2171199256 @default.
• W1989519898 cites W2361587666 @default.
• W1989519898 cites W2423421797 @default.
• W1989519898 cites W4250178961 @default.
• W1989519898 cites W4254544684 @default.
• W1989519898 doi "https://doi.org/10.1006/viro.1997.8779" @default.
• W1989519898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9356333" @default.
• W1989519898 hasPublicationYear "1997" @default.
• W1989519898 type Work @default.
• W1989519898 sameAs 1989519898 @default.
• W1989519898 citedByCount "15" @default.
• W1989519898 countsByYear W19895198982015 @default.
• W1989519898 countsByYear W19895198982016 @default.
• W1989519898 crossrefType "journal-article" @default.
• W1989519898 hasAuthorship W1989519898A5000780125 @default.
• W1989519898 hasAuthorship W1989519898A5035996420 @default.
• W1989519898 hasAuthorship W1989519898A5071476197 @default.
• W1989519898 hasAuthorship W1989519898A5085681127 @default.
• W1989519898 hasBestOaLocation W19895198981 @default.
• W1989519898 hasConcept C104317684 @default.
• W1989519898 hasConcept C127561419 @default.
• W1989519898 hasConcept C1491633281 @default.
• W1989519898 hasConcept C153911025 @default.
• W1989519898 hasConcept C159654299 @default.
• W1989519898 hasConcept C170493617 @default.
• W1989519898 hasConcept C197462201 @default.
• W1989519898 hasConcept C203014093 @default.
• W1989519898 hasConcept C2776913467 @default.
• W1989519898 hasConcept C2777371288 @default.
• W1989519898 hasConcept C2778461978 @default.
• W1989519898 hasConcept C2993002077 @default.
• W1989519898 hasConcept C54355233 @default.
• W1989519898 hasConcept C55493867 @default.
• W1989519898 hasConcept C79879829 @default.
• W1989519898 hasConcept C81885089 @default.
• W1989519898 hasConcept C86803240 @default.
• W1989519898 hasConcept C95444343 @default.
• W1989519898 hasConceptScore W1989519898C104317684 @default.
• W1989519898 hasConceptScore W1989519898C127561419 @default.
• W1989519898 hasConceptScore W1989519898C1491633281 @default.
• W1989519898 hasConceptScore W1989519898C153911025 @default.
• W1989519898 hasConceptScore W1989519898C159654299 @default.
• W1989519898 hasConceptScore W1989519898C170493617 @default.
• W1989519898 hasConceptScore W1989519898C197462201 @default.
• W1989519898 hasConceptScore W1989519898C203014093 @default.
• W1989519898 hasConceptScore W1989519898C2776913467 @default.
• W1989519898 hasConceptScore W1989519898C2777371288 @default.
• W1989519898 hasConceptScore W1989519898C2778461978 @default.
• W1989519898 hasConceptScore W1989519898C2993002077 @default.
• W1989519898 hasConceptScore W1989519898C54355233 @default.
• W1989519898 hasConceptScore W1989519898C55493867 @default.
• W1989519898 hasConceptScore W1989519898C79879829 @default.
• W1989519898 hasConceptScore W1989519898C81885089 @default.
• W1989519898 hasConceptScore W1989519898C86803240 @default.

• next