FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989533893> ?p ?o ?g. }

• W1989533893 endingPage "645" @default.
• W1989533893 startingPage "639" @default.
• W1989533893 abstract "L-Glutamate is considered the most important excitatory amino acid in the mammalian brain. Strict control of its concentration in the brain interstitial fluid is important to maintain neurotransmission and avoid excitotoxicity. The role of astrocytes in handling L-glutamate transport and metabolism is well known, however endothelial cells may also play an important role through mediating brain-to-blood L-glutamate efflux. Expression of excitatory amino acid transporters has been demonstrated in brain endothelial cells of bovine, human, murine, rat and porcine origin. These can account for high affinity concentrative uptake of L-glutamate from the brain interstitial fluid into the capillary endothelial cells. The mechanisms in between L-glutamate uptake in the endothelial cells and L-glutamate appearing in the blood are still unclear and may involve a luminal transporter for L-glutamate, metabolism of L-glutamate and transport of metabolites or a combination of the two. However, both in vitro and in vivo studies demonstrated blood-to-brain transport of L-glutamate, at least during pathological events. This review summarizes the current knowledge on the brain-to-blood L-glutamate efflux hypothesis including possible mechanisms to account for the transport, in vivo studies on blood glutamate scavenging and potential clinical relevance of the phenomenon." @default.
• W1989533893 created "2016-06-24" @default.
• W1989533893 creator A5010563977 @default.
• W1989533893 creator A5018587328 @default.
• W1989533893 creator A5044156865 @default.
• W1989533893 date "2014-11-01" @default.
• W1989533893 modified "2023-10-05" @default.
• W1989533893 title "Glutamate Efflux at the Blood–Brain Barrier: Cellular Mechanisms and Potential Clinical Relevance" @default.
• W1989533893 cites W1496689787 @default.
• W1989533893 cites W1509349969 @default.
• W1989533893 cites W1576577565 @default.
• W1989533893 cites W16603568 @default.
• W1989533893 cites W1900227502 @default.
• W1989533893 cites W1965527923 @default.
• W1989533893 cites W1966128832 @default.
• W1989533893 cites W1967174704 @default.
• W1989533893 cites W1969130431 @default.
• W1989533893 cites W1971043748 @default.
• W1989533893 cites W1972161610 @default.
• W1989533893 cites W1972183007 @default.
• W1989533893 cites W1976989006 @default.
• W1989533893 cites W1981425827 @default.
• W1989533893 cites W1984338769 @default.
• W1989533893 cites W1991479116 @default.
• W1989533893 cites W1991913680 @default.
• W1989533893 cites W1992357222 @default.
• W1989533893 cites W1993022928 @default.
• W1989533893 cites W1993331896 @default.
• W1989533893 cites W1995588151 @default.
• W1989533893 cites W2002261163 @default.
• W1989533893 cites W2002905697 @default.
• W1989533893 cites W2003068392 @default.
• W1989533893 cites W2003198568 @default.
• W1989533893 cites W2003410399 @default.
• W1989533893 cites W2008418681 @default.
• W1989533893 cites W2010229759 @default.
• W1989533893 cites W2010307662 @default.
• W1989533893 cites W2011398156 @default.
• W1989533893 cites W2012237785 @default.
• W1989533893 cites W2018336666 @default.
• W1989533893 cites W2019929877 @default.
• W1989533893 cites W2029379167 @default.
• W1989533893 cites W2030352252 @default.
• W1989533893 cites W2038317423 @default.
• W1989533893 cites W2042480247 @default.
• W1989533893 cites W2050270653 @default.
• W1989533893 cites W2054660542 @default.
• W1989533893 cites W2058172582 @default.
• W1989533893 cites W2062618424 @default.
• W1989533893 cites W2064443971 @default.
• W1989533893 cites W2067727345 @default.
• W1989533893 cites W2070139095 @default.
• W1989533893 cites W2075617478 @default.
• W1989533893 cites W2078517229 @default.
• W1989533893 cites W2090945850 @default.
• W1989533893 cites W2104522961 @default.
• W1989533893 cites W2106731245 @default.
• W1989533893 cites W2108655765 @default.
• W1989533893 cites W2118206249 @default.
• W1989533893 cites W2124053400 @default.
• W1989533893 cites W2128744963 @default.
• W1989533893 cites W2130962254 @default.
• W1989533893 cites W2136487679 @default.
• W1989533893 cites W2137491003 @default.
• W1989533893 cites W2137757295 @default.
• W1989533893 cites W2142097068 @default.
• W1989533893 cites W2153116158 @default.
• W1989533893 cites W2159400209 @default.
• W1989533893 cites W2160644313 @default.
• W1989533893 cites W2164056657 @default.
• W1989533893 cites W2167974925 @default.
• W1989533893 cites W2171111385 @default.
• W1989533893 cites W2183452160 @default.
• W1989533893 cites W2243408637 @default.
• W1989533893 cites W2472553960 @default.
• W1989533893 cites W4210979710 @default.
• W1989533893 doi "https://doi.org/10.1016/j.arcmed.2014.11.004" @default.
• W1989533893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25446623" @default.
• W1989533893 hasPublicationYear "2014" @default.
• W1989533893 type Work @default.
• W1989533893 sameAs 1989533893 @default.
• W1989533893 citedByCount "27" @default.
• W1989533893 countsByYear W19895338932014 @default.
• W1989533893 countsByYear W19895338932015 @default.
• W1989533893 countsByYear W19895338932016 @default.
• W1989533893 countsByYear W19895338932017 @default.
• W1989533893 countsByYear W19895338932018 @default.
• W1989533893 countsByYear W19895338932019 @default.
• W1989533893 countsByYear W19895338932020 @default.
• W1989533893 countsByYear W19895338932022 @default.
• W1989533893 crossrefType "journal-article" @default.
• W1989533893 hasAuthorship W1989533893A5010563977 @default.
• W1989533893 hasAuthorship W1989533893A5018587328 @default.
• W1989533893 hasAuthorship W1989533893A5044156865 @default.
• W1989533893 hasConcept C104317684 @default.
• W1989533893 hasConcept C113657865 @default.
• W1989533893 hasConcept C149011108 @default.
• W1989533893 hasConcept C150903083 @default.

• next