FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989536066> ?p ?o ?g. }

• W1989536066 endingPage "164" @default.
• W1989536066 startingPage "157" @default.
• W1989536066 abstract "The alkylphosphocholine oleylphosphocholine (OlPC) represents a potential new therapy for the treatment of canine leishmaniosis caused by Leishmania infantum. The aim of the present study was to evaluate the efficacy and safety of OlPC in a small cohort of dogs naturally infected with L. infantum and defined as clinically sick (LeishVet stages II and III). A total of eight dogs were included in the study and were treated orally with 4 mg/kg OlPC for 14 days. Dogs were assessed at the clinical and parasitological level at four time points during a total follow-up period of 90 days (before treatment and at 15, 30, and 90 days post-treatment onset). Ln-PCR, real-time quantitative PCR, antibody testing (IFAT), and culture of bone marrow aspirates were evaluated at the four time points. OlPC treatment induced a rapid and satisfactory clinical recovery in terms of clinical score reduction and weight gain, and treatment efficacy was found to be associated with a decrease in bone marrow parasitic load. Serological titers measured by IFAT were stable in any of the treated dogs at any time point after treatment. OlPC was well tolerated and no severe adverse events were noted in any of the treated dogs; even some dogs showed slight intestinal disorders. This proof-of-principle study is the first to show that short oral treatment with OlPC improves clinical signs of canine L. infantum leishmaniosis, highlighting the need to perform additional studies to optimize the dosing regimen and to assess long-term treatment efficacy of this drug." @default.
• W1989536066 created "2016-06-24" @default.
• W1989536066 creator A5011460345 @default.
• W1989536066 creator A5030033312 @default.
• W1989536066 creator A5030093166 @default.
• W1989536066 creator A5035740812 @default.
• W1989536066 creator A5039003179 @default.
• W1989536066 creator A5044803305 @default.
• W1989536066 creator A5045993387 @default.
• W1989536066 creator A5046904700 @default.
• W1989536066 creator A5048253790 @default.
• W1989536066 creator A5078469622 @default.
• W1989536066 date "2013-11-06" @default.
• W1989536066 modified "2023-10-01" @default.
• W1989536066 title "First study on efficacy and tolerability of a new alkylphosphocholine molecule (oleylphosphocholine—OlPC) in the treatment of canine leishmaniosis due to Leishmania infantum" @default.
• W1989536066 cites W116276269 @default.
• W1989536066 cites W1772992353 @default.
• W1989536066 cites W1963508090 @default.
• W1989536066 cites W1965289186 @default.
• W1989536066 cites W1969776415 @default.
• W1989536066 cites W1984594388 @default.
• W1989536066 cites W1985088770 @default.
• W1989536066 cites W1985409310 @default.
• W1989536066 cites W1995725063 @default.
• W1989536066 cites W2004504718 @default.
• W1989536066 cites W2010994178 @default.
• W1989536066 cites W2015475724 @default.
• W1989536066 cites W2022696494 @default.
• W1989536066 cites W2026729702 @default.
• W1989536066 cites W2031127010 @default.
• W1989536066 cites W2032574711 @default.
• W1989536066 cites W2038771703 @default.
• W1989536066 cites W2042880479 @default.
• W1989536066 cites W2051247838 @default.
• W1989536066 cites W2054881085 @default.
• W1989536066 cites W2056656305 @default.
• W1989536066 cites W2062659743 @default.
• W1989536066 cites W2063434214 @default.
• W1989536066 cites W2064246035 @default.
• W1989536066 cites W2079048552 @default.
• W1989536066 cites W2084208767 @default.
• W1989536066 cites W2086166468 @default.
• W1989536066 cites W2088238276 @default.
• W1989536066 cites W2092793728 @default.
• W1989536066 cites W2101255948 @default.
• W1989536066 cites W2127056287 @default.
• W1989536066 cites W2128166966 @default.
• W1989536066 cites W2131902485 @default.
• W1989536066 cites W2137352804 @default.
• W1989536066 cites W2141583445 @default.
• W1989536066 cites W2165148728 @default.
• W1989536066 cites W2169398729 @default.
• W1989536066 cites W4211253687 @default.
• W1989536066 cites W4233424756 @default.
• W1989536066 cites W4250179682 @default.
• W1989536066 cites W64981325 @default.
• W1989536066 doi "https://doi.org/10.1007/s00436-013-3638-2" @default.
• W1989536066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24192865" @default.
• W1989536066 hasPublicationYear "2013" @default.
• W1989536066 type Work @default.
• W1989536066 sameAs 1989536066 @default.
• W1989536066 citedByCount "15" @default.
• W1989536066 countsByYear W19895360662014 @default.
• W1989536066 countsByYear W19895360662015 @default.
• W1989536066 countsByYear W19895360662016 @default.
• W1989536066 countsByYear W19895360662017 @default.
• W1989536066 countsByYear W19895360662018 @default.
• W1989536066 countsByYear W19895360662021 @default.
• W1989536066 countsByYear W19895360662022 @default.
• W1989536066 countsByYear W19895360662023 @default.
• W1989536066 crossrefType "journal-article" @default.
• W1989536066 hasAuthorship W1989536066A5011460345 @default.
• W1989536066 hasAuthorship W1989536066A5030033312 @default.
• W1989536066 hasAuthorship W1989536066A5030093166 @default.
• W1989536066 hasAuthorship W1989536066A5035740812 @default.
• W1989536066 hasAuthorship W1989536066A5039003179 @default.
• W1989536066 hasAuthorship W1989536066A5044803305 @default.
• W1989536066 hasAuthorship W1989536066A5045993387 @default.
• W1989536066 hasAuthorship W1989536066A5046904700 @default.
• W1989536066 hasAuthorship W1989536066A5048253790 @default.
• W1989536066 hasAuthorship W1989536066A5078469622 @default.
• W1989536066 hasBestOaLocation W19895360661 @default.
• W1989536066 hasConcept C126322002 @default.
• W1989536066 hasConcept C149172746 @default.
• W1989536066 hasConcept C159654299 @default.
• W1989536066 hasConcept C197934379 @default.
• W1989536066 hasConcept C203014093 @default.
• W1989536066 hasConcept C2776555147 @default.
• W1989536066 hasConcept C2777625542 @default.
• W1989536066 hasConcept C2778375690 @default.
• W1989536066 hasConcept C2778689377 @default.
• W1989536066 hasConcept C2779225474 @default.
• W1989536066 hasConcept C2780026642 @default.
• W1989536066 hasConcept C2780035454 @default.
• W1989536066 hasConcept C2780423678 @default.
• W1989536066 hasConcept C2781257258 @default.
• W1989536066 hasConcept C2781413609 @default.
• W1989536066 hasConcept C45189115 @default.

• next