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- W1989563793 abstract "We overview here our recent work on the thermodynamic view of allosteric regulation and communication. Starting from the geometry-based prediction of regulatory binding sites in a static structure, we move on to exploring a connection between ligand binding and the intrinsic dynamics of the protein molecule. We describe here two recently introduced measures, binding leverage and leverage coupling, which allow one to analyze the molecular basis of allosteric regulation. We discuss the advantages of these measures and show that they work universally in proteins of different sizes, oligomeric states, and functions. We also point the problems that have to be solved before completing an atomic level description of allostery, and briefly discuss ideas for computational design of allosteric drugs. This article is part of a Special Issue entitled: The emerging dynamic view of proteins: Protein plasticity in allostery, evolution and self-assembly." @default.
- W1989563793 created "2016-06-24" @default.
- W1989563793 creator A5033504184 @default.
- W1989563793 date "2013-05-01" @default.
- W1989563793 modified "2023-10-16" @default.
- W1989563793 title "Thermodynamics of allostery paves a way to allosteric drugs" @default.
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- W1989563793 doi "https://doi.org/10.1016/j.bbapap.2013.01.024" @default.
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