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• W1989563881 abstract "TM3-O-05 Introduction: Many epidemiologic studies provide evidence of an association between daily counts of mortality and airborne particles, measured as either particulate matter less than 10 μm in diameter (PM10) or less than 2.5 μm (PM2.5 or fine particles). Little is known, however, about the relative toxicity of the specific constituents of the particle mix. Such information provides additional evidence of biologic plausibility and mechanisms, and should help prioritize pollution abatement efforts. In this study, we examined the associations between 22 different species of PM2.5 and daily mortality in 6 heavily populated California counties. We focused on the full population as well as on socio-demographic subgroups. Methods: We collected daily data from 2000 through 2003 on mortality, meteorology, and fine particles and constituents such as elemental and organic carbon (EC and OC), nitrates, sulfates, zinc, copper, and manganese. We examined associations of these species with daily counts of all-cause mortality and several cause-specific subcategories (respiratory, cardiovascular, ischemic heart disease, and diabetes). We also examined these associations among several subpopulations, including those over age 65, males, females, non-high school graduates, whites, and Hispanics. Poisson multiple regression models incorporating natural splines were used to control for time-varying covariates that could affect daily counts of mortality, including seasonality and weather. Results: We observed associations between several species of PM2.5 and different mortality categories. Of note, exposures to PM2.5, OC, EC, nitrates, zinc, and iron were all associated with mortality from cardiovascular disease and with those over age 65, males, Hispanics, and non-high school graduates. The effects per μg/m3 for several of the components were greater than that of generic PM2.5. Associations were particularly strong during the winter months and among groups with lower economic status. Conclusions: This multicounty analysis adds to the growing body of evidence linking fine particles with significant adverse health effects. The general results suggest that in California, different sources of PM2.5 are associated with mortality but with varying toxicity. Pollution from mobile sources, particularly diesel engines, and woodstoves appear to be particularly important." @default.
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• W1989563881 date "2006-11-01" @default.
• W1989563881 modified "2023-10-16" @default.
• W1989563881 title "Fine Particle Species and Daily Mortality: Investigating Sensitive Subgroups" @default.
• W1989563881 doi "https://doi.org/10.1097/00001648-200611001-00512" @default.
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