FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989577817> ?p ?o ?g. }

• W1989577817 endingPage "382" @default.
• W1989577817 startingPage "373" @default.
• W1989577817 abstract "Parameters of the virus-specific T-cell response were analysed in order to dissect the contribution of CD4+ and CD8+ T cells to cell-mediated immunity to lymphocytic choriomeningitis virus. In MHC class II deficient mice, initial T-cell responsiveness was not impaired, but virus clearance was delayed, and virus-specific Td activity declined more rapidly. Furthermore, class I restricted Tc memory appeared to be impaired in these mice. To directly evaluate the role of CD4+ cells in virus clearance and T-cell mediated inflammation, MHC class I deficient mice were also studied. No virus-specific delayed-type hypersensitivity reaction was detected following infection of the footpad, and only a few mice died from intracerebral challenge. However analysis of markers of T-cell activation as well as direct evaluation of CSF inflammation unveiled a low degree of T-cell activation and a chronic cellular exudate. This low-grade response was associated with some degree of virus control as organ titres were lower in these animals than in matched T-cell deficient nu/nu mice or class I deficient mice treated with anti-CD4 monoclonal antibody. This confirms that CD4+ cells are not needed to induce a virus-specific CD8+ T-cell response, but our findings strongly suggest that CD4+ T cells are critical for maintaining full antiviral immunity. Furthermore, CD4+ T cells per se have a low potential for mediating virus-specific inflammation that is associated with a low degree of virus control." @default.
• W1989577817 created "2016-06-24" @default.
• W1989577817 creator A5012450083 @default.
• W1989577817 creator A5021217421 @default.
• W1989577817 creator A5046951838 @default.
• W1989577817 date "1994-10-01" @default.
• W1989577817 modified "2023-10-16" @default.
• W1989577817 title "The Role of CD4+ T Cells in Cell-Mediated Immunity to LCM V: Studies in MHC Class I and Class II Deficient Mice" @default.
• W1989577817 cites W1480839898 @default.
• W1989577817 cites W1500857249 @default.
• W1989577817 cites W1529781388 @default.
• W1989577817 cites W1530692519 @default.
• W1989577817 cites W1534851574 @default.
• W1989577817 cites W1546312669 @default.
• W1989577817 cites W1557586692 @default.
• W1989577817 cites W1564904553 @default.
• W1989577817 cites W1570339538 @default.
• W1989577817 cites W1589224876 @default.
• W1989577817 cites W1656874207 @default.
• W1989577817 cites W1669573844 @default.
• W1989577817 cites W1704711026 @default.
• W1989577817 cites W1819121222 @default.
• W1989577817 cites W1981729022 @default.
• W1989577817 cites W2008070068 @default.
• W1989577817 cites W2009598375 @default.
• W1989577817 cites W2016472376 @default.
• W1989577817 cites W2042321162 @default.
• W1989577817 cites W2043265823 @default.
• W1989577817 cites W2046341790 @default.
• W1989577817 cites W2055198199 @default.
• W1989577817 cites W2057040903 @default.
• W1989577817 cites W2060199817 @default.
• W1989577817 cites W2061298251 @default.
• W1989577817 cites W2070180624 @default.
• W1989577817 cites W2090851364 @default.
• W1989577817 cites W2093143038 @default.
• W1989577817 cites W2095408546 @default.
• W1989577817 cites W2126087475 @default.
• W1989577817 cites W2131170930 @default.
• W1989577817 cites W2140279098 @default.
• W1989577817 cites W2150613199 @default.
• W1989577817 cites W2153032998 @default.
• W1989577817 cites W2170401536 @default.
• W1989577817 cites W2472182922 @default.
• W1989577817 cites W36604328 @default.
• W1989577817 cites W4313310077 @default.
• W1989577817 doi "https://doi.org/10.1111/j.1365-3083.1994.tb03477.x" @default.
• W1989577817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7939408" @default.
• W1989577817 hasPublicationYear "1994" @default.
• W1989577817 type Work @default.
• W1989577817 sameAs 1989577817 @default.
• W1989577817 citedByCount "69" @default.
• W1989577817 countsByYear W19895778172012 @default.
• W1989577817 countsByYear W19895778172014 @default.
• W1989577817 countsByYear W19895778172015 @default.
• W1989577817 countsByYear W19895778172016 @default.
• W1989577817 countsByYear W19895778172017 @default.
• W1989577817 countsByYear W19895778172019 @default.
• W1989577817 countsByYear W19895778172022 @default.
• W1989577817 crossrefType "journal-article" @default.
• W1989577817 hasAuthorship W1989577817A5012450083 @default.
• W1989577817 hasAuthorship W1989577817A5021217421 @default.
• W1989577817 hasAuthorship W1989577817A5046951838 @default.
• W1989577817 hasConcept C154317977 @default.
• W1989577817 hasConcept C159047783 @default.
• W1989577817 hasConcept C167672396 @default.
• W1989577817 hasConcept C170627219 @default.
• W1989577817 hasConcept C193419808 @default.
• W1989577817 hasConcept C202751555 @default.
• W1989577817 hasConcept C203014093 @default.
• W1989577817 hasConcept C207936829 @default.
• W1989577817 hasConcept C2522874641 @default.
• W1989577817 hasConcept C2776090121 @default.
• W1989577817 hasConcept C2776914184 @default.
• W1989577817 hasConcept C2778814158 @default.
• W1989577817 hasConcept C2779341262 @default.
• W1989577817 hasConcept C2780190958 @default.
• W1989577817 hasConcept C55493867 @default.
• W1989577817 hasConcept C86803240 @default.
• W1989577817 hasConcept C8891405 @default.
• W1989577817 hasConceptScore W1989577817C154317977 @default.
• W1989577817 hasConceptScore W1989577817C159047783 @default.
• W1989577817 hasConceptScore W1989577817C167672396 @default.
• W1989577817 hasConceptScore W1989577817C170627219 @default.
• W1989577817 hasConceptScore W1989577817C193419808 @default.
• W1989577817 hasConceptScore W1989577817C202751555 @default.
• W1989577817 hasConceptScore W1989577817C203014093 @default.
• W1989577817 hasConceptScore W1989577817C207936829 @default.
• W1989577817 hasConceptScore W1989577817C2522874641 @default.
• W1989577817 hasConceptScore W1989577817C2776090121 @default.
• W1989577817 hasConceptScore W1989577817C2776914184 @default.
• W1989577817 hasConceptScore W1989577817C2778814158 @default.
• W1989577817 hasConceptScore W1989577817C2779341262 @default.
• W1989577817 hasConceptScore W1989577817C2780190958 @default.
• W1989577817 hasConceptScore W1989577817C55493867 @default.
• W1989577817 hasConceptScore W1989577817C86803240 @default.
• W1989577817 hasConceptScore W1989577817C8891405 @default.
• W1989577817 hasIssue "4" @default.

• next