FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989581783> ?p ?o ?g. }

• W1989581783 endingPage "159" @default.
• W1989581783 startingPage "159" @default.
• W1989581783 abstract "Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebo-controlled, double-blind study Daniela Buonocore,1 Angelo Lazzeretti,2 Pedro Tocabens,3 Vincenzo Nobile,4 Enza Cestone,4 Giada Santin,5 Maria G Bottone,5,6 Fulvio Marzatico11Laboratory of Pharmacobiochemistry, Nutrition and Nutraceutical of Wellness, Department of Biology and Biotechnology “L Spallanzani”, University of Pavia, Pavia, Italy; 2GMC Pharma SRL, Milan, Italy; 3Actafarma Laboratorios, Madrid, Spain; 4Farcoderm SRL European Network for Tests in Dermatology and Wellness, Pavia, 5Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology “L Spallanzani”, 6Institute of Molecular Biology CNR, Section of Histochemistry and Cytometry, University of Pavia, Pavia, ItalyBackground: Skin is constantly exposed to pro-oxidant environmental stress from several sources, including air pollutants, ultraviolet solar light, and chemical oxidants. Reactive oxygen species have been implicated in age-related skin disorders. Dietary bioactive antioxidant compounds, such as polyphenols, have beneficial effects on skin health. The advantage of a nutritional administration route is that blood delivers nutraceutical bioactive compounds continuously to all skin compartments, ie, the epidermis, dermis, and subcutaneous fat. The purpose of this study was to evaluate the topical and systemic effects of a dietary supplement containing resveratrol and procyanidin on age-related alterations to the skin, the skin antioxidant pool, and systemic oxidative stress levels.Methods: An instrumental study was performed in 50 subjects (25 treated with supplements and 25 with placebo) to identify clinical features induced by chronoaging or photoaging. Product efficacy was evaluated after 60 days of treatment in terms of in vivo and in situ skin hydration, elasticity, and skin roughness levels, systemic oxidative stress levels by plasmatic derivatives of reactive oxygen metabolites and oxyadsorbent tests, and extent of the skin antioxidant pool.Results: After 60 days of treatment, values for systemic oxidative stress, plasmatic antioxidant capacity, and skin antioxidant power had increased significantly. Additionally, skin moisturization and elasticity had improved, while skin roughness and depth of wrinkles had diminished. Intensity of age spots had significantly decreased, as evidenced by improvement in the individual typological angle.Conclusion: Nutraceutical and pharmacological intervention with a supplement characterized by a specific blend of resveratrol and procyanidin may be a promising strategy to support treatments for the reduction of skin wrinkling, as well as reducing systemic and skin oxidative stress.Keywords: antiaging, nutraceuticals, procyanidin, resveratrol supplementation, skin" @default.
• W1989581783 created "2016-06-24" @default.
• W1989581783 creator A5016166589 @default.
• W1989581783 creator A5024570887 @default.
• W1989581783 creator A5031346974 @default.
• W1989581783 creator A5036426303 @default.
• W1989581783 creator A5044230609 @default.
• W1989581783 creator A5065813217 @default.
• W1989581783 creator A5075005371 @default.
• W1989581783 creator A5078462901 @default.
• W1989581783 date "2012-10-01" @default.
• W1989581783 modified "2023-10-14" @default.
• W1989581783 title "Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebo-controlled, double-blind study" @default.
• W1989581783 cites W1511966243 @default.
• W1989581783 cites W1549328326 @default.
• W1989581783 cites W1614684224 @default.
• W1989581783 cites W1731618434 @default.
• W1989581783 cites W1942251818 @default.
• W1989581783 cites W1984534858 @default.
• W1989581783 cites W1986472678 @default.
• W1989581783 cites W1988007485 @default.
• W1989581783 cites W2000967440 @default.
• W1989581783 cites W2001327595 @default.
• W1989581783 cites W2002928259 @default.
• W1989581783 cites W2004307486 @default.
• W1989581783 cites W2006049488 @default.
• W1989581783 cites W2023777632 @default.
• W1989581783 cites W2031136439 @default.
• W1989581783 cites W2031213396 @default.
• W1989581783 cites W2040884797 @default.
• W1989581783 cites W2055780054 @default.
• W1989581783 cites W2059891869 @default.
• W1989581783 cites W2072264650 @default.
• W1989581783 cites W2081093364 @default.
• W1989581783 cites W2099979796 @default.
• W1989581783 cites W2103450921 @default.
• W1989581783 cites W2135643979 @default.
• W1989581783 cites W2138188139 @default.
• W1989581783 cites W2144600435 @default.
• W1989581783 cites W2151028908 @default.
• W1989581783 cites W2151309354 @default.
• W1989581783 cites W2153278852 @default.
• W1989581783 cites W2154587590 @default.
• W1989581783 cites W2160770872 @default.
• W1989581783 cites W2165292984 @default.
• W1989581783 cites W2166515237 @default.
• W1989581783 cites W2338528278 @default.
• W1989581783 cites W2340234859 @default.
• W1989581783 cites W2419269917 @default.
• W1989581783 cites W36061735 @default.
• W1989581783 cites W625482605 @default.
• W1989581783 cites W65269860 @default.
• W1989581783 cites W81899995 @default.
• W1989581783 doi "https://doi.org/10.2147/ccid.s36102" @default.
• W1989581783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3469214" @default.
• W1989581783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23071399" @default.
• W1989581783 hasPublicationYear "2012" @default.
• W1989581783 type Work @default.
• W1989581783 sameAs 1989581783 @default.
• W1989581783 citedByCount "46" @default.
• W1989581783 countsByYear W19895817832013 @default.
• W1989581783 countsByYear W19895817832014 @default.
• W1989581783 countsByYear W19895817832015 @default.
• W1989581783 countsByYear W19895817832016 @default.
• W1989581783 countsByYear W19895817832017 @default.
• W1989581783 countsByYear W19895817832018 @default.
• W1989581783 countsByYear W19895817832019 @default.
• W1989581783 countsByYear W19895817832020 @default.
• W1989581783 countsByYear W19895817832021 @default.
• W1989581783 countsByYear W19895817832022 @default.
• W1989581783 countsByYear W19895817832023 @default.
• W1989581783 crossrefType "journal-article" @default.
• W1989581783 hasAuthorship W1989581783A5016166589 @default.
• W1989581783 hasAuthorship W1989581783A5024570887 @default.
• W1989581783 hasAuthorship W1989581783A5031346974 @default.
• W1989581783 hasAuthorship W1989581783A5036426303 @default.
• W1989581783 hasAuthorship W1989581783A5044230609 @default.
• W1989581783 hasAuthorship W1989581783A5065813217 @default.
• W1989581783 hasAuthorship W1989581783A5075005371 @default.
• W1989581783 hasAuthorship W1989581783A5078462901 @default.
• W1989581783 hasBestOaLocation W19895817831 @default.
• W1989581783 hasConcept C126322002 @default.
• W1989581783 hasConcept C142724271 @default.
• W1989581783 hasConcept C16005928 @default.
• W1989581783 hasConcept C17857428 @default.
• W1989581783 hasConcept C185592680 @default.
• W1989581783 hasConcept C204787440 @default.
• W1989581783 hasConcept C27081682 @default.
• W1989581783 hasConcept C2776151105 @default.
• W1989581783 hasConcept C2776816829 @default.
• W1989581783 hasConcept C2776960578 @default.
• W1989581783 hasConcept C2778004101 @default.
• W1989581783 hasConcept C31903555 @default.
• W1989581783 hasConcept C55493867 @default.
• W1989581783 hasConcept C70899900 @default.
• W1989581783 hasConcept C71924100 @default.
• W1989581783 hasConcept C77784730 @default.
• W1989581783 hasConcept C98274493 @default.

• next