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- W1989587289 abstract "A simple in vitro approach where sun formulations are spread on a quartz slide and placed over human skin cells in culture is proposed as a convenient test for photoprotection assessment at the DNA level. Using the comet assay, DNA strand breaks and oxidative DNA damage were detected. Then, accumulation of p53 protein was studied as a marker for UV-induced genotoxic stress. Such a method was used to compare formulations with different photostability. Spectroradiometry showed that a photo-unstable formulation lost its effectiveness in UVA screening when pre-irradiated by simulated sunlight. As a consequence, such a formulation was not as protective as a photostable one at the genomic level." @default.
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- W1989587289 date "2002-11-01" @default.
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- W1989587289 title "Comet assay combined with p53 detection as a sensitive approach for DNA photoprotection assessment <i>in vitro</i>" @default.
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- W1989587289 doi "https://doi.org/10.1034/j.1600-0625.11.s.1.8.x" @default.
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