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- W1989594677 abstract "The immunological activities of five synthetic peptides of the prM protein of dengue-2 (DEN-2) virus containing B cell epitopes were evaluated in BALB/c mice. Two peptides elicited neutralizing antibodies against all four DEN serotypes. Virus-specific proliferative responses were demonstrated in mice immunized with four of the five peptides, demonstrating the presence of T cell epitopes. Mice immunized with three of the five peptides conjugated with bovine albumin showed statistically significant levels (P<0.05) of protection when challenged with DEN-2 virus. These results could constitute the basis for the establishment of the role of DEN virus pre and M antigens in the development of anti-flaviviral vaccines." @default.
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- W1989594677 date "2002-03-01" @default.
- W1989594677 modified "2023-10-18" @default.
- W1989594677 title "Immune response to synthetic peptides of dengue prM protein" @default.
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- W1989594677 doi "https://doi.org/10.1016/s0264-410x(01)00515-1" @default.
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