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• W1989606481 abstract "Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease of the central nervous system. IL-12p40 monokines play a critical role in the generation of EAE-inducing CD4 + T cells. Here we show that IL-12 directly upregulates the expression of the adhesion molecule, P-selectin glycoprotein ligand (PSGL-1), on B10.PL MBP-TCR transgenic T cells during their initial encounter with antigen. Pre-incubation of IL-12-stimulated myelin-reactive CD4 + T cells with a blocking antibody against PSGL-1 reduced the incidence and severity of EAE. We conclude that IL-12-driven PSGL-1 expression can facilitate the development of autoimmune demyelination." @default.
• W1989606481 created "2016-06-24" @default.
• W1989606481 creator A5039903543 @default.
• W1989606481 date "1998-11-01" @default.
• W1989606481 modified "2023-09-26" @default.
• W1989606481 title "The comeback of the elusive “suppressor” cell: an update on the regulatory network in EAE" @default.
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• W1989606481 doi "https://doi.org/10.1016/s0923-2494(99)80009-1" @default.
• W1989606481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9923637" @default.
• W1989606481 hasPublicationYear "1998" @default.
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