FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989606919> ?p ?o ?g. }

• W1989606919 endingPage "817" @default.
• W1989606919 startingPage "811" @default.
• W1989606919 abstract "Sir2 has been shown to be essential for transcriptional silencing and longevity provided by calorie restriction in Saccharomyces cerevisiae and Caenorhabditis elegans. In this study, we investigated the role for its mammalian homologue, SIRT1, in hematopoietic cells. SIRT1 inhibitor, nicotinamide (NA), promoted and its activator, resveratrol, inhibited the differentiation of murine bone marrow c-KithighSca-1+Lineage− (KSL) cells during the culture system ex vivo. To further clarify the roles of SIRT1 in hematopoietic cells, we isolated KSL cells from fetal liver of SIRT1 knockout (KO) mice and cultured them for 5 days, because SIRT1 KO mice die shortly after the delivery. In agreement with the results from the experiments using NA and resveratrol, KSL cells isolated from SIRT1 KO mice more apparently differentiated and lost the KSL phenotype than those from wild-type (WT) mice. Furthermore, in each of colony assay, replating assay, or serial transplantation assay, SIRT1 KO KSL cells lost earlier the characteristics of stem cells than WT KSL cells. In addition, we found that SIRT1 maintains prematurity of hematopoietic cells through ROS elimination, FOXO activation, and p53 inhibition. These results suggest that SIRT1 suppresses differentiation of hematopoietic stem/progenitor cells and contributes to the maintenance of stem cell pool." @default.
• W1989606919 created "2016-06-24" @default.
• W1989606919 creator A5009434641 @default.
• W1989606919 creator A5019149806 @default.
• W1989606919 creator A5023792530 @default.
• W1989606919 creator A5031873210 @default.
• W1989606919 creator A5032401017 @default.
• W1989606919 creator A5033832686 @default.
• W1989606919 creator A5037063267 @default.
• W1989606919 creator A5045409061 @default.
• W1989606919 creator A5045468227 @default.
• W1989606919 creator A5055453369 @default.
• W1989606919 creator A5066455212 @default.
• W1989606919 creator A5081091831 @default.
• W1989606919 date "2012-02-01" @default.
• W1989606919 modified "2023-09-29" @default.
• W1989606919 title "NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells" @default.
• W1989606919 cites W1969408132 @default.
• W1989606919 cites W1990574061 @default.
• W1989606919 cites W1997224953 @default.
• W1989606919 cites W2012753961 @default.
• W1989606919 cites W2013463110 @default.
• W1989606919 cites W2017965105 @default.
• W1989606919 cites W2042500733 @default.
• W1989606919 cites W2045459881 @default.
• W1989606919 cites W2046205800 @default.
• W1989606919 cites W2053213876 @default.
• W1989606919 cites W2056247303 @default.
• W1989606919 cites W2061770641 @default.
• W1989606919 cites W2061774727 @default.
• W1989606919 cites W2068223162 @default.
• W1989606919 cites W2069752613 @default.
• W1989606919 cites W2084289371 @default.
• W1989606919 cites W2089258536 @default.
• W1989606919 cites W2102614059 @default.
• W1989606919 cites W2118204731 @default.
• W1989606919 cites W2124595934 @default.
• W1989606919 cites W2125121177 @default.
• W1989606919 cites W2128610489 @default.
• W1989606919 cites W2135387645 @default.
• W1989606919 cites W2135470678 @default.
• W1989606919 doi "https://doi.org/10.1016/j.bbrc.2012.01.109" @default.
• W1989606919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22306819" @default.
• W1989606919 hasPublicationYear "2012" @default.
• W1989606919 type Work @default.
• W1989606919 sameAs 1989606919 @default.
• W1989606919 citedByCount "56" @default.
• W1989606919 countsByYear W19896069192012 @default.
• W1989606919 countsByYear W19896069192013 @default.
• W1989606919 countsByYear W19896069192014 @default.
• W1989606919 countsByYear W19896069192015 @default.
• W1989606919 countsByYear W19896069192016 @default.
• W1989606919 countsByYear W19896069192017 @default.
• W1989606919 countsByYear W19896069192018 @default.
• W1989606919 countsByYear W19896069192019 @default.
• W1989606919 countsByYear W19896069192020 @default.
• W1989606919 countsByYear W19896069192021 @default.
• W1989606919 countsByYear W19896069192022 @default.
• W1989606919 countsByYear W19896069192023 @default.
• W1989606919 crossrefType "journal-article" @default.
• W1989606919 hasAuthorship W1989606919A5009434641 @default.
• W1989606919 hasAuthorship W1989606919A5019149806 @default.
• W1989606919 hasAuthorship W1989606919A5023792530 @default.
• W1989606919 hasAuthorship W1989606919A5031873210 @default.
• W1989606919 hasAuthorship W1989606919A5032401017 @default.
• W1989606919 hasAuthorship W1989606919A5033832686 @default.
• W1989606919 hasAuthorship W1989606919A5037063267 @default.
• W1989606919 hasAuthorship W1989606919A5045409061 @default.
• W1989606919 hasAuthorship W1989606919A5045468227 @default.
• W1989606919 hasAuthorship W1989606919A5055453369 @default.
• W1989606919 hasAuthorship W1989606919A5066455212 @default.
• W1989606919 hasAuthorship W1989606919A5081091831 @default.
• W1989606919 hasConcept C104317684 @default.
• W1989606919 hasConcept C109159458 @default.
• W1989606919 hasConcept C127561419 @default.
• W1989606919 hasConcept C134018914 @default.
• W1989606919 hasConcept C153911025 @default.
• W1989606919 hasConcept C185592680 @default.
• W1989606919 hasConcept C201750760 @default.
• W1989606919 hasConcept C203014093 @default.
• W1989606919 hasConcept C2776536020 @default.
• W1989606919 hasConcept C2776816829 @default.
• W1989606919 hasConcept C2778086970 @default.
• W1989606919 hasConcept C2778305200 @default.
• W1989606919 hasConcept C2778707264 @default.
• W1989606919 hasConcept C2780007613 @default.
• W1989606919 hasConcept C28328180 @default.
• W1989606919 hasConcept C55493867 @default.
• W1989606919 hasConcept C64927066 @default.
• W1989606919 hasConcept C86803240 @default.
• W1989606919 hasConcept C95444343 @default.
• W1989606919 hasConceptScore W1989606919C104317684 @default.
• W1989606919 hasConceptScore W1989606919C109159458 @default.
• W1989606919 hasConceptScore W1989606919C127561419 @default.
• W1989606919 hasConceptScore W1989606919C134018914 @default.
• W1989606919 hasConceptScore W1989606919C153911025 @default.
• W1989606919 hasConceptScore W1989606919C185592680 @default.
• W1989606919 hasConceptScore W1989606919C201750760 @default.

• next