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• W1989609003 abstract "A study of DR4 subtypes has been done in Spanish unrelated controls and insulin-dependent diabetics by using dot blot hybridization with specific DR4B1 exon-2 oligonucleotides and automated dideoxy DNA sequencing. Dw15-DQw8 is the predominant DR4 subtype present in our normal population (37%); this DR4 frequency characteristic singles out our population from all other Caucasoids tested so far and may also be a marker of the original Iberian paleo-North African population. Dw15-DQw8 is not significantly increased in our insulin-dependent diabetics sample and despite its relative high frequency in the control population it does not have a bearing in lowering insulin-dependent diabetes mellitus frequency of DR4-positive Spaniards. In addition, no particular DR4 split is by itself significantly increased in Spanish diabetics; this may indicate that selective diabetogenic environmental factors may be working upon DR4-positive individuals, but on genes (or gene products) other than DR or at least not upon the polymorphic sites of DRB1 exon-2 products." @default.
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• W1989609003 date "1991-01-01" @default.
• W1989609003 modified "2023-10-16" @default.
• W1989609003 title "High frequency of the HLA-DRB1 0405-(Dw15)-DQw8 haplotype in Spaniards and its relationship to diabetes susceptibility" @default.
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• W1989609003 doi "https://doi.org/10.1016/0198-8859(91)90053-c" @default.
• W1989609003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1774197" @default.
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